舌下含服硝苯地平致脑损害加重26例的临床分析

Clinical analysis on impairment of brain function of 26 cases after sublingual Nifedipine

目的观察高血压急症患者舌下含服硝苯地平降压时对大脑功能的影响。方法应用脑电地形图、动态脑电图和动态血压仪监测56例高血压急症患者舌下含服硝苯地平(20mg)前后的血压、脑电图及脑电地形图变化情况,并进行分析。结果服药后2h内有3例患者脑电图改善,27例无变化,26例脑电图异常程度明显增加,θ和δ及其频段功率值明显升高(均P<0.01),这些患者的血压降低幅度也明显大于脑电图改善者及无明显改变者(均P<0.01)。结论含服硝苯地平降压急骤时,可造成或加重脑损害。

Objective To observe the cffect of sublingual Nifedipine on brain function in emergency cases with hypertension. Methods The changes of blood pressure, electroencephalogram （EEG） and brain electrical activity mapping （BEAM） in 56 patients with emergency hypertension before and afler sublingual Nifedipine were analyzed. Results Within 2 hours ＇after sublingual medicine, EEG results improved in 3 cases and did not change in 27. More severe abnormal EEG changes were seen in 26 cases, θ and δ band power rose evidently in these patients （ all P 〈 0. 01 ） , also they had more obvious decrease of blood pressure than other patients （ all P 〈0. 01 ）. Conclusion A sudden drop in blood pressure by sublingual Nifedepine may result in or aggravate impairment of brain function.