9Ushio H,Nakao A,Supajatura V,et al.MD -2 is required for the full responsiveness of mast cells to LPS but not to PGN [ J ].Biochem Biophys Res Commun.2004,323(2) :491 ～498.
1Hoshino K, Takeuchi O, Kawai T, et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysac-charide: evidence for TLR4 as the Lps gene product. J Immunol,1999,162: 3749-3752.
2Yang RB, Mark MR, Gray A, et al. Toll-like receptor-2 mediates lipopolysaccharide-indueed cellular signalling. Nature, 1998, 395:284-288.
3Kirschning CJ, Wesche H, Merrill Ayres T, et al. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J Exp Med, 1998,188:2091-2097.
4Yang RB, Mark MR, Gumey AL, et al. Signaling events induced by lipopolysaccharide-activated toll-like receptor 2. J Immunol,1999,163:639-643.
5Brightbill HD, Library DH, Krutzik SR, et al. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.Science, 1999,285 : 732-736.
6Qureshi ST, Iariviere L, Leveque G, et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (TLR4). J Exp Med, 1999,189:615-625.
7Pohorak A, He X, Smimova I, et al. Defective LPS aignaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 geae. Science, 1998,282 : 2085-2088.
8Chow JC, Young DW, Golenbock DT, et al. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem, 1999,274:10689-10692.
9Shimazu R, Akashi S, Ogata H, etal. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med., 1999,189:1777-1782.
10Ohashi K, Burkart V, Flohe S, et al. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol,2000,164:558-561.
8Yamaguchi M,Kojima T,Kanekawa M,et al.Neuropeptides stimulate production of Medical interleukin-1 beta,interleukin-6,and tumor necrosis factor-alpha in human dental pulp cells[J].Inflamm Res,2004,53(5):199.
9Ingham E,Waiters CE,Eady EA,et al.Inflammation in acne vulgaris:failure of skin micro-organisms to modulate keratinocyte interleukin 1 alpha production in vitro[J].Dermatology,1998,196(1):86.
10Graham GM,Farrar MD,Cruse-Sawyer JE,et al.Proinflammatory cytokine production by human keratinocytes stimulated with Propionibacterium acnes and P acnes groel[J].Br J Dermatol,2004,150(3):421-428.
