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TGF-β1基因多态性、癌变机制及临床价值的研究进展 被引量:7

Gene polymorphism and carcinogenesis mechanism of TGF-β1 and its diagnostic values for hepatocellular carcinoma.
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出处 《胃肠病学和肝病学杂志》 CAS 2005年第6期649-653,共5页 Chinese Journal of Gastroenterology and Hepatology
关键词 肝细胞癌 转化生长因子 TGF-Β1 Hepatocellular carcinoma Transforming growth factor TGF-β1
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  • 1Blode GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med,2000,342:1650-1658.
  • 2Bachem MG, Meyer DM, Melchior R,et al. Activation of rat liver perisminusoidal lipocytes by transforming growth factors derived from myofibroblast-like cells. a potential mechanism of self-perpetuationin in liver fibrogenesis. J Clin Invest,1992,89:19-27.
  • 3Dixon MC, Yeaman SJ, Aguis L,et al. Transforming growth factor beta increases the activity of phospatidate phosphohydrolase-1 in rat hepatocytes.Biochem Biophys Res Commun,1997,230:365-369.
  • 4Gewaltig J, Mangasser-Stephan K, Gartung C, et al. Association of polymorphisms of the transforming growth factorβ1 gene with the rate of progression of HCV-induced liver fibrosis. Clin Chim Acta, 2002,316:83-94.
  • 5Bataller R, North KE, Brenner DA. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology,2003;37:493-503.
  • 6Luedecking EK, DeKosky ST, Mehdi H, et al. Analysis of genetic polymorphisms in the transforming growth factorβ1 gene and the risk of Alzheimer's disease. Hum Genet, 2000,106:565-569.
  • 7Dunning AM, Ellis PD, McBride S, et al.A transforming growth factor beta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer. Cancer Res, 2003,63:2610-2615.
  • 8de Souza AP, Trevilatto PC, Scarel-Caminaga RM, et al. Analysis of the TGF beta1 promoter polymorphism (C-509T) in patients with chronic perodontitis. J Clin Periodontol, 2003,30:519-523.
  • 9Kim JY, Lee HS, Im JP, et al. Association of transforming growth factor beta1 gene polymorphisms with a hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection. Exp Mol Med, 2003,35:196-202.
  • 10Kawaguchi Y, Furushima K, Sugimori K, et al. Association between polymorphism of the transforming growth factor beta1 gene with the radiologic characteristic and ossification of the posterior longitudinal ligament. Spine, 2003,28:1424-1426.

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