青光眼遗传学研究的现状与挑战

Progresses and challenges in genetic studies of glaucoma

青光眼是常见且病变不可逆转的严重致盲眼病,遗传因素对于青光眼的发生具有重要作用。人类基因组计划的完成及相关分子遗传学技术在青光眼研究领域的应用,使青光眼的病因学研究取得了重要进展。目前人们难以预计新的研究成果将对青光眼的预防、早期诊断及治疗所产生的重要影响,但却引发出一系列值得思考的问题,这可能预示着青光眼遗传学研究方向的变化趋势。

Glaucoma is one of the leading causes of irreversible blindness. The genetic changes play an important role in the pathogenesis of glaucoma. Progress in human genome project （HGP） and the application of molecular genetics in the study of glaucoma has leaded to an important progress in the understanding of etiology of glaucoma. It is still difiqcult to predict the influence of these progresses on the early diagnosis, prevention and treatment of glaucoma. However, this may provide a series of problem that reauire exploration and shows the changing direction of glaucoma study in the future.