摘要
目的 观察和比较常规分割剂量每周照射7天与每周照射5天两种方法治疗Ⅲ期食管癌的疗效及放射反应。方法 对96例Ⅲ期食管癌首治病例随机分成每周照射7天组(治疗组)和每周照射5天组(对照组),治疗组48例,2.0Gy/次,1次/天,7天/周,共60~70Gy,30~35分次,30~35天完成;对照组48例,2.0Gy/次,1次/天,5天/周,共60~70Gy,30—35分次,40~47天完成。结果 治疗组与对照组1、2、3年生存率分别为77.1%、62.5%、50%和66.7%、37.5%、22.9%,治疗组高于对照组(P〈0.05)。1、2、3年局控率分别为81.3%、64.6%、54.1%和68.7%、41.6%、31.2%,治疗组高于对照组(P〈0.05)。急性放射性食管炎发生率分别为10.4%和6.2%,差别无显著意义(P〉0.05)。出血穿孔的发生率分别为6.2%和4.3%,差别无显著意义(P〉0.05)。结论 常规分割剂量7天/周照射比5天/周照射可提高疗效,未明显增加不良反应。
Objective To evaluate the effect of radiotherapy on stage Ⅲ a esophageal cancer with conventional fraction dose 7 - day - per - week. Methods A total of 96 patients with stage Ⅲ a esophageal cancer were divided into 2 groups : the 7 - day - per - week group ( 48 patients ) and the 5 - day - per - week group ( 48 patients). Patients in the 7 - day - per - week group received a total dose of 60 - 70 GY/30 - 35fraction/30 - 35 days, and the 5 -day-per-week group received a total dose of 60 -70GY/30 -35 fraction/40 -47 days. Results The 1 - ,2 - ,3 - year survival rates of the 7 - day - per - week group and the 5 - day - per - week group were 77.1% ,62. 5% ,50% and 66.7% ,37.5% ,29.2% , ( P 〈0.05 ). The 1 -, 2 - , 3 - year local tumor control rates of the two groups were 81.3% ,64.7% ,54.1 and 68.7% ,41.6% ,31.2%, ( P 〈0.05 ). The aute esophigitis and massive hemorrhage of the two groups were 10.4%,6.2% and 6. 2% ,4. 3% (P〉0.05).Conclusion The 7-day-per-week radiotherapy can improve the local tumor control rate and survival rate of stage Ⅲa esophageal cancer, but not additional side reaction.
出处
《现代肿瘤医学》
CAS
2006年第1期28-30,共3页
Journal of Modern Oncology
关键词
食管癌
照射疗法
放射剂量分次
预后
esophageal neoplasms
radiothaeapy
dose fractionation
prognosis