摘要
实验以司盘(Span)和胆固醇(CH)为主要原料,通过薄膜分散法法制备了头孢唑啉钠囊泡。用透射电镜考察了囊泡的形态和构造,并对可能影响包封的各种实验条件进行了优化。实验表明:在50℃超声40 min的条件下,Span40与CH用量比为4∶3时形成的囊泡对1.0 mg/mL的注射用头孢唑啉钠平均包封率达50%以上,而且制备的头孢唑啉钠囊泡在模拟胃流体和模拟肠流体中均有缓释作用。
The niosomes loaded with Cefazolin Sodium was prepared from Spanand persion of film. The vehicles were visualized by transmission electron microscopy. Some Cholestesterol, using aqueous disexperimental condition have been optimized. The resuts show that the entrapment efficiency of niosomes prepared by Span40 with Cholesterol (4:3, V/V) reached 50% for Cefazlin Sodium for injection. Furthermore, insimulated gastric and intestinal fluid, the release rate of Cefazolin Sodium niosomes is slower than that free cefazolin sodium solution.
出处
《化工时刊》
CAS
2005年第12期14-15,31,共3页
Chemical Industry Times