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新抗精神病药物阿立哌唑的药代动力学 被引量:10

Pharmacokinetics of aripiprazole, a new psychotic drug
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摘要 阿立哌唑具有稳定多巴胺和5-羟色胺系统的作用,作为一类新的抗 精神病药物,应用于临床,已在中国上市。本文主要就阿立哌唑在人体的药代 动力学特征及与其他药物的相互作用做一综述。 Aripiprazole has come into the market in China as a new kind of antipsychotic drug and it has been referred to as a dopamine - serotonin system stabilizer. The pharmacokinetic characters and drug interactions with other agents were reviewed.
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2005年第6期470-474,共5页 The Chinese Journal of Clinical Pharmacology
关键词 阿立哌唑 药代动力学 药物相互作用 aripiprazole pharmacokinetics drug interaction
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  • 1Kikuchi T, Tottori K, Uwahodo Y, et al. 7 - (4 - [4 - (2,3 - Di-chlorophenyl) - 1 - piperazinyl] butyloxy) - 3,4 - dihydro - 2 (1H)- quinolinone ( OPC - 14597 ), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity[ J]. J Pharmacol Exp Ther, 1995;274: 329 - 336.
  • 2Shapiro DA, Renock S, Arrington E, et al. Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology [J].Neuropsychopharmacol, 2003 ;28 : 1400 - 1411.
  • 3Abilify tablet [ J/OL ]. http ://www. emea. eu. int /humandocs/pdfs/epar/abilify 089304 en6. pdf ,2004 -08 -09.
  • 4FDA approves abilify (aripiprazole) for treatment of acute bipolar mania, including manic and mixed episodes[ J/OL]. http://www. bms.com/news/press/data/fg_press_release_ 5024. html ,2004 - 10 - 10.
  • 5DeLeon A, Patel NC, Crismon ML. Aripiprazole: a comprehensive review of its pharmacology, clinical efficacy, and tolerability [J]. Clin Ther, 2004 ;26:649 - 666.
  • 6Burris KD, Molski TF, Xu C, et al. Aripiprazole, a novel antipsychotic, is a high - affinity partial agonist at human dopamine D2 receptors[J]. J Pharmacol Exp Ther,2002;302:381 -389.
  • 7Lawler CP, Prioleau C, Lewis MM, et al. Interactions ofthe novel antipsychotic aripiprazole ( OPC - 14597 ) with dopamine and serotonin receptor subtypes[J]. Neuropsychopharmacol, 1999 ;20:612 - 627.
  • 8Jordan S, Koprivica V, Chen R, et al. The antipsychotic aripiprazole is a potent, partial agonist at the human 5 -HT1A receptor[J]. Eur J Pharmacol, 2002;441:137 - 140.
  • 9Kane JM, Carson WH, Saha AR, et al. Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder[J]. J Clin Psychiatry, 2002 ;63:763 - 771.
  • 10Potkin SG, Saha AR, Kujawa M J, et al. Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorder [J]. Arch Gen Psychiatry, 2003 ;60:681 - 690.

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