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钾通道开放剂研究的新进展

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摘要 目的:介绍钾通道开放剂的结构和分类以及最近几年的研究进展。方法:对国内外大量相关文献进行综合分析和整理。结果:以钾通道为靶标,近年来研制出许多钾通道开放剂(KCO),应用于治疗心血管疾病。结论:KCO用于治疗心血管疾病,特别是在抗高血压和心肌保护方面,具有广阔的前景。
出处 《中国医院药学杂志》 CAS CSCD 北大核心 2005年第11期1071-1073,共3页 Chinese Journal of Hospital Pharmacy
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  • 1[2]Sato T, Sasaki N, Seharaseyon J, O'Rourke B, Marban E. Selective pharmacological agents implicate mitochondrial but not sarcolemmal K (ATP) channels in ischemic cardioprotecion[J]. Circulation, 2000; 101(20):2418-23
  • 2[3]Ichinose M, Yonemochi H, Sato T, Saikawa T. Diazoxide triggers cardioprotection against apoptosis induced by oxidative stress[J]. Am J Physiol Heart Circ Physiol, 2003; 284(6):H2235-41
  • 3[7]Minners J, Lacerda L, McCarthy J, Meiring JJ, Yellon DM, Sack MN. Ischemic and pharmacological preconditioning in Girardi cells and C2C12 myotubes induce mitochondrial uncoupling[J]. Circ Res, 2001;89(9):787-92
  • 4[8]Murata M, Akao M, O'Rourke B, Marban E. Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca2+ overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection[J]. Circ Res, 2001;89(10):891-8
  • 5[9]Holmuhamedov EL, Wang L, Terzic A. ATP-sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria[J]. J Physiol, 1999;519(2):347-60
  • 6[10]Lawrence CL, Billups B, Rodrigo GC, Standen NB. The KATP channel opener diazoxide protects cardiac myocytes during metabolic inhibition without causing mitochondrial depolarization or flavoprotein oxidation[J]. Br J Pharmacol, 2001;134(3):535-42
  • 7[11]Grimmsmann T, Rustenbeck I. Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria[J]. Br J Pharmacol, 1998;123(5);781-8
  • 8[12]Dzeja PP, Bast P, Ozcan C, Valverde A, Holmuhamedov EL, Van Wylen DG, et al. Targeting nucleotide-requiring enzymes: implications for diazoxide-induced cardioprotection[J]. Am J Physiol Heart Circ Physiol, 2003;284(4):H1048-56
  • 9[1]Garlid KD, Paucek P, Yarov-Yarovoy V, Murray HN, Darbenzio RB, D'Alonzo AJ, et al. Cardioprotective effectof diazoxide and its interaction with mitochondrial ATP-sensitive K-channels: possible mechanism of cardioprotection[J]. Circ Res, 1997;81(7):1072-82
  • 10He H M,中国药理学报,1998年,19卷

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