醋柳黄酮对家兔血液流变性、血小板及凝血功能的影响

Effects of total flavones of Hippophae rhamnoides L.on blood viscosity,platelet and blood coagulation in rabbits

目的:研究醋柳黄酮(TFH)对家兔血液流变性、血小板及凝血功能的影响.方法:测定醋柳黄酮灌胃给药对家兔血黏度、血小板聚集、血栓形成和凝血功能的影响.结果:醋柳黄酮灌胃1.5～10 mg·kg-1可显著降低家兔全血黏度、血浆黏度;抑制ADP诱导的家兔血小板聚集;抑制血栓形成;明显延长活化部分凝血酶原时间(APTT).结论:醋柳黄酮具有改善家兔血液流变性、抑制血栓形成作用.

OBJECTIVE To study the effects of total flavones of Hippophae rhamnoides L （TFH） on blood viscosity,platelet and blood coagulation in rabbits. METHODS Blood viscosity, platelet aggregation, thrombosis and blood coagulation was measured after rabbit was fed with TFH RESULTS TFH significantly reduced plasma and serum viscosity in rabbits, inhibited platelet aggregation induced by ADP, reduced thrombosis and markedly enhanced activated partial thrombopealastin time （APTT）. CONCLUSION TFH possessed the ability of improving blood viscosity and inhibiting thrombosis.