毛细支气管炎患儿血浆CGRP、VIP RIA的意义

Clinical Significance of Changes of Plasma CGRP and VIP Levels in Infants with Bronchiolitis

目的:通过检测毛细支气管炎患儿急性期和恢复期血浆中降钙素基因相关肽(CGRP)、血管活性肠肽(VIP)的含量,探讨毛细支气管炎患儿血浆CGRP、VIP放射免疫分析(RIA)的意义。方法:本文采用放射免疫分析测定了31例毛细支气管炎患儿急性期和恢复期血浆CGRP、VIP的浓度,以35例正常婴幼儿血浆CGRP、VIP的浓度为对照。结果:毛细支气管炎患儿急性期血浆CGRP浓度明显高于恢复期及正常对照组婴幼儿(P<0.05);恢复期CGRP浓度有所下降,但仍高于正常对照组(P<0.05),三组间有显著差异(F=82.50,P<0.01);毛细支气管炎患儿急性期血浆VIP浓度明显低于恢复期及正常对照组婴幼儿(P<0.05);恢复期VIP浓度有所升高,但仍低于正常对照组(P<0.05);三组之间有显著性差异(F=300.20,P<0.01)。结论:CGRP、VIP定量分析结果表明毛细支气管炎患儿血浆CGRP、VIP含量与病程紧密相关。CGRP、VIP RIA对于小儿毛细支气管炎发病机制的研究以及了解其发病病程和指导治疗有着重要的意义。

Objective To explore the clinical significance of changes of calcitonin gene - related peptide （CGRP） and vasoactive intestinal peptide （VIP） levels in infants （2～24months） with bronehiolitis. Methods Plasma levels of CGRP and VIP were determined with RIA in 31 infants with bronehiolitis both during acute infection and convalescence as well as in 35 controls. Results Plasma CGRP levels in patients during acute infection were significantly higher than those in patients during convalescence and in controls （ P 〈 0.05 ）. Levels of CGRP dropped during convalescence, but still remained significantly higher than those in controls （ P 〈 0.05 ）. The reverse was true for the plasma VIP levels. The plasma VIP levels in patients during acute infection were significantly lower than those in patients during convalescence and in controls （P 〈 0.05）. During convalescence, the plasma VIP levels rose but remained significantly lower than those in controls （P 〈 0.05 ）. Conclusion There were dynamic changes of plasma CGRP and VIP levels in the course of infant bronehiolitis and the two peptides played opposite roles.