TSH受体抗体测定的临床意义

Clinical Significance of Determination of Serum TRAb Levels in Patients with Thyroid Diseases

目的:探讨血清TRAb的测定变化对G raves甲亢的临床意义。方法:应用放射免疫受体分析法(RRA)对302例甲状腺疾病患者及52例正常健康人的血清TRAb的值进行比较。结果:甲亢组TRAb的测定值阳性率为86.3%;甲亢缓解组TRAb的测定值阳性率为74.5%;甲亢治愈组TRAb的测定值阳性率为32.1%;甲亢复发组TRAb的测定值阳性率为90.3%;单纯性甲状腺肿组TRAb的测定值阳性率为0;甲瘤组TRAb的测定值阳性率为0;甲亢组、甲亢缓解组、甲亢治愈组、甲亢复发组与正常对照组相比有显著性差异(P<0.01);单纯性甲状腺肿组、甲瘤组与正常对照组相比无显著性差异(P>0.05)。结论:TRAb的测定对G raves甲亢的治疗具有重要的参考价值。

Objective To investigate the clinical Significance of determination of serum thyroid stimulating hormone receptor antibody （TRAb） levels in patients with thyroid diseases, especially in patients with Graves＇ disease. Methods Serum TRAb levels were determined with radio - receptor assay （RRA） in 302 patients with various thyroid diseases and 52 controls. Results In patients with Graves＇ disease before treatment （n = 62） the positive rate of TRAb was 86.3%. In patients with Graves＇ diseases improved after treatment （n =60）, the positive rate was 74.5% ; in those clinically cured （n =68） the positive rate was 32.1%. In 58 patients with Graves＇ disease who relapsed after apparently cure, the positive rate of TRAb rose to 90.3%. However, there were no positive TRAb cases in 23 patients with simple goiter and 31 patients with benign thyroid adenomas. Also, there were no positive TRAb cases in the controls. Conclusion TRAb levels correspond well with the severity of Graves＇ disease.