牙周病患者治疗前后血清IL-2、IL-6和TNF-α水平及其临床意义

Clinical Significance of Changes of Serum IL-2,IL-6 and TNF-α Levels After Treatment in Patients with Periodontitis

目的:探讨了牙周病患者血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)和肿瘤坏死因子(TNF-α)在牙周病发生、发展过程中的浓度变化及相互关系。方法:应用放射免疫分析检测了48例牙周病患者血清IL-2、IL-6和TNF-α含量的变化,并与35例正常健康人作比较。结果:牙周病患者在治疗前血清IL-6和TNF-α水平非常显著的高于正常人组(P<0.01)而IL-2水平则显著的低于正常人组(P<0.01),经系统治疗后(一个月)除IL-6和TNF-α水平与正常人组比较无差异外(P>0.05),IL-2与正常人组比较仍有显著性差异(P<0.05)。结论:细胞因子IL-2、IL-6和TNF-α在牙周病的发生、发展过程中的相互作用、观察其浓度变化对探讨其发病机理、预防和指导用药均有重要价值。

Objective To investigate the changes of serum IL - 2, IL - 6 and TNF - α levels after one month of comprehensive treatment in patients with periodontitis. Methods Serum IL-2,IL-6 and TNF - α levels were measured with RIA in 48 patients with periodontitis both before and atier treatment as well as in 35 controls. Results Before treatment, serum levels of IL - 6, TNF - α in the patients were significantly higher and IL - 2 levels were significantly lower than those in the controls （ both P 〈 0. 01 ）. After one month of treatment, the IL - 6, TNF - α levels in the patients were not much different from those in controls （ P 〉 0. 05 ）. However, the IL - 2 levels were still significantly lower than those in controls （ P 〈 0.05）. Conclusion There was disturbance of immuno modulation in patients with periodontitis as expressed by the changes of cytokines levels in the course of the disease.