^(125)I种子源组织间植入近距离治疗恶性肿瘤的疗效观察及临床意义

Observation on the Therapeutic Effect of ^(125)I Radioactive Seeds Interstitial Implantation for Treatment of Advanced Malignancies

目的:观察125I粒子组织间植入治疗晚期肿瘤的疗效。方法:125I种子源作为近距离放疗植入于难以根除性切除的各项恶性肿瘤(肝、胰、前列腺等)共35例,随访其治疗效果。结果:所有病人均仍存活,术后3~6月检查:肿块消失6例(17%+),缩小26例(74%+),变化不明显者2例,只有1例继续增大,疼痛基本缓解。结论:本法作为不能根治的恶性肿瘤的辅助治疗,有较好的效果,安全可行。

Objective To investigate the therapeutic efficacy of ^125Ⅰ radioactive seeds interstitial implantation for late malignancies. Methods ^125Ⅰseeds as source of brachytherapy were implanted interstitially into 35 patients with late malignancies not radically resectable （liver, pancreas, prostate cancers etc. ） and the patients were closely followed. Results To date, all patients survive. Three to six months after the procedure, the tumor disappeared totally in six cases （ 17% ^＋ ） and diminished in size in 26 cases （74% ^＋ ）. Tumor size did not change in 2 cases, only in one case the tumor expanded further. Basically, pain was satisfactorily alleviated. Conclusion As a part of adjuvant therapy for late malignancies, this method is safe and applicable with satifactory therapeutic effect.