血清胞苷脱氨酶在活动性类风湿关节炎诊疗中的意义

Significance of Determination of Serum Cytidine Deaminase(CD) Levels for Diagnosis of Active Rheumatoid Arthritis(RA)

目的:探讨测定血清胞苷脱氨酶(CD)含量对活动性类风湿关节炎(RA)患者的诊疗价值。方法:采用分光光度法测定血清中的胞苷脱氨酶活性,同时用免疫比浊法测定C反应蛋白(CRP),魏氏法测定血沉(ESR)。结果:活动性RA组血清CD含量(14.80±2.11)U/m l,显著高于正常对照组(4.86±1.86)U/m l,(P<0.01);CRP(51.46±20.43)mg/L和ESR(85.03±27.6)mm/1h明显高于正常对照组(3.40±2.21)mg/L,(13.04±4.89)mm/1h(均P<0.01);活动性RA患者组CD含量与ESR、CRP成直线关系,相关系数r分别为0.6324(P<0.01)与0.8013(P<0.01)。结论:血清CD活性可作为活动性RA患者急性感染的早期诊断指标,对活动性RA患者的预后判断亦有临床价值。

Objective To determine the clinical value of measurement of serum cytidine deaminase （CD） levels in patients with active rheumatoid arthritis （RA）. Methods Serum levels of CD were detected with spectrophotometry in 33 patients with active RA and 60 controls. The erythrocyte sedimentation rate （ESR） and CRP content were also determined in both groups. Results The serum CD contents in patients with active RA（ 14.80 ± 2.11U/ml） were significantly higher than those in controls（4.86 ± 1.86 U/ml,P 〈0.01 ）. The CRP contents （51.46 ±20.43mg/L） and ESR readings （85.03 ± 27.6mm/h） in the patients were also significantly higher than those in the controls （3.40 ± 2.21 mg/L and 13.04 ± 4.89mm/h respectively, all P 〈 0.01 ）. In the patients, the serum CD contents were linearly positively correlated with the ESR contents and CRP readings （r =0. 6324 and 0. 8013 respectively, P 〈0. 01 ）. Conclusion Serum CD is an early biochemical marker for diagnosis of active rhematoid arthritis and is also of prognostic value.