肝病患者血清血小板生成素水平与血小板计数关系的初步探讨

Study on the Relationship Between the Serum Thrombopoietin(TPO) Levels and Blood Platalet Counts in Patients with Various Kinds of Liver Diseases

目的:探讨肝病患者血清中血小板生成素(TPO)水平与血小板(PLT)减少的关系。方法:用ELISA方法测定正常人群的及肝病患者的TPO水平。结果:TPO水平在急性肝炎、慢性肝炎轻、中、重度、肝硬化患者与正常人群比较差异无统计学意义(P>0.05);而血小板计数除了急性肝炎组外均差异有统计学意义(P<0.05)。肝病患者血小板正常组(37例)与减少组(40例)TPO水平比较,差异有统计学意义[(136.38±93.49)与(98.65±65.20)μg/L,(P<0.05)];但TPO水平与血小板计数不相关(r=0.1572,P>0.05)。结论:肝病患者血清TPO水平降低可能是致血小板减少的诸多原因之一。

Objective To study the relationship between serum thrombopoietin （TPO） levels and thrombocytopenia in patients with various kinds of liver diseases. Methods Serum TPO levels were determined with ELISA in 102 patients with various kinds of liver diseases （ acute hepatitis n =9, chronic hepatitis n = 80, hepatic cirrhosis n = 13, etiology, HBV infection n = 73, HBV ± HEV n = 13, HEV n = 8, HCV n = 6 autoimmune hepatitis n = 2） and 30 controls. Results The serum TPO levels in patients with various kinds of liver diseases were not significantly different from those in the controls （P 〉 0.05）. However, the blood platalet counts were significantly lower in all the patients （with the exception of the nine patients with acute hepatitis） than those in the controls （ P 〈 0. 05 ）. If we split the patients with liver diseases into two groups ： those with normal platalet count （n = 37） and those with thrombocyto- penia （ n =40）, then their TPO levels （ 136.38±93. 491μg/L and 98.65 ± 65.20μg/L） were significantly different from each other （ P 〈 0.05 ）. Yet, as a whole, the serum TPO levels were not correlated with the blood platalet count （ r = 0. 1572, P 〉 0.05 ）. Oonclusion The lower TPO levels in patients with liver diseases could be only one of the many factors leading to thrombocytopenia.