海洛因滥用者血清腺苷脱氨酶检测及临床意义

DETERMINATION OF SERUM ADENOSINE DEAMINASE IN HEROIN ABUSERS AND ITS CLINICAL SIGNIFICANCE

目的:了解海洛因滥用者血清中腺苷脱氨酶(adenosine deaminase,ADA)的活性水平及其临床意义。方法:在美国BECKMAN COULTER公司出品的SYNCHRON CX9 ALX全自动生化分析仪上对238例海洛因滥用者及38例健康对照者血清中腺苷脱氨酶(ADA)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)及γ-谷氨酰转肽酶(GGT)活性同时进行测定。结果:与健康对照组相比,各滥用组的血清ALP,GGT活性差异无统计学意义(P>0.05);滥用2个月组的血清ADA,ALT,AST差异无统计学意义(P>0.05);滥用6个月以上各组血清ADA,ALT,AST活性高于健康对照组,差异有统计学意义(P<0.01,P<0.05);滥用组血清ADA活性随滥用时间延长明显增高,各组间两两比较,差异有统计学意义(F=569.8,P<0.001)。ADA活性与ALT,AST活性呈正相关,与ALP,GGT无相关关系。结论:海洛因滥用者血清中ADA活性增高可以判断滥用者肝实质损伤程度,估计其滥用时间,对脱毒治疗有重要临床意义。

Objective： To investigate the clinical significance of serum activity level of adenosine deaminase （ ADA ） in heroin abusers.Methods： The ADA, alanine aminotransferase （ ALT ）, aspartate aminotransferase（AST）, alkaline phosphatase（ALP）, and γ- glutamyl transpeptidase（GGT） activity levels in the serum of 238 heroin abusers and 38 healthy individuals were measured by SYNCHRON CX9 ALX automatic biochemical analyzer. Results： The ADA, ALT and AST activity level in the serum of the abusers who had abused heroin over 6 months were significantly higher than that of the controls （ P 〈 0.01 ; P 〈 0.05）. The ADA activity levels increased in accordance with the duration of drug abuse （ F = 569.8, P 〈 0.001）, and correlated with ALT and AST activity levels rather than with ALP and GGT activity levels in the serum. Conclusion ： The ADA activity levels in the serum of heroin abusers can reflect the damage degree of liver and have important clinical significance to detoxification.