造血细胞发育分化相关转录因子研究

Transcription factors in hematopoietic cell development and differentiation

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摘要造血细胞发育分化是一个非常复杂的过程,转录因子在此过程中起了重要的调控作用,并且转录因子之间发生相互调控,从而形成复杂的调控网络。对造血相关转录因子的研究有助于揭示造血细胞发育分化的分子机制,为造血干细胞更有效广泛的应用于临床提供理论指导。 The development and differentiation of hematopoietc cells are very complex process in which transcription factors regulate the specific-lineage gene expression in synergic or antagonistic forms and form a complicated network. The study of hematopoietic transcription factors is necessary for the demonstration of the regulating mechanism of hematopoiesis and may support direction for the clinical application of hematopoietic stem cells （HSC）.

作者李长燕杨晓明

机构地区军事医学科学院放射与辐射医学研究所

出处《军事医学科学院院刊》 CSCD 北大核心 2005年第6期558-562,共5页 Bulletin of the Academy of Military Medical Sciences

基金国家高技术研究发展计划(2004AA221180) 国家自然科学基金(30400075)资助项目

关键词血细胞生成造血干细胞转录因子发育调控 hematopoiesis hematopoietic stem cells （ HSC ） transcription factors development regulation

分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]

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2005年第6期

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