儿童与少年急性非淋巴细胞白血病的细胞遗传学研究

Cytogenetic Studies on Childhood and Juvenile Acute Nonlymphocytic Leukemia (ANLL)

对33例15岁以下急性非淋巴细胞白血病患者进行了细胞遗传学研究,21例(63.6％)有获得性染色体异常。15例为t(8;21),主要属M_2亚型。2例检出近四倍体克隆,皆属M_6.21三体,1q三体,t(15;17)和复杂异常各1例。前两者属M_2,皆由骨髓增生异常综合征演变而来,后两者分属M_3和M_5。

Cytogenetic studies were performed on 33 children with ANLL under the age of 15. In 21 of them (63.6%) acquired chromosomal abnormalities were observed. 15 cases showed t (8; 21) and they belonged mostly to M2 morphologically. A near-tetraploid clone was detected in 2 patients with M6. Each of the four cases had 21 trisomy, lq trisomy, t (15; 17) and complicated abnormality respectively. The first two of them belonged to M2, which developed from myelodysplastic syndrome, while the latter two belonged to M3 and M5 respectively.