急性脑血管病患者血浆血栓素及前列环素浓度的变化

Changes of Plasma TXB_2, 6-Keto-PGF_(1α) Levels in Patients with Acute Cerebrovascular Disease

本文应用放射免疫法测定了30例急性脑血管病患者(8例合并冠心病)血浆TXB_2和6Keto-PGF_(1α)的浓度。发现:TXB_2浓度,30例病人高于正常对照组(P<0.01);重症病人高于轻症病人(P<0.05);合并冠心病的病人高于未合并冠心病的病人(P<0.001)。各组病人6Keto-PGF_(1α)浓度均低于对照组。结果表明:TXA_2-PGI_2失衡与急性脑血管病密切相关。TXB_2浓度与病情程度正相关。TXA_2可能在冠心病和脑血管病的相互影响中发挥作用。

30 patients with acute cerebrovascular disease were divided into serious group and mild group and plasma TXB2 and 6-Keto-PGF1α were measured by radio-immunoassay. Among them 8 were accompanied with ischemic heart disease (IHD). Plasma TXB2 levels in 30 patients were higher than that in the normal controls (P<0.01). Plasma TXB2 levels in serious group were higher than in mild group (P<0.05). 8 patients with IHD had plasma TXB2 levels higher than those in the other 22 patients (P<0.001). In contrast with TXB2, plasma 6-Keto-PGF1α levels in patients with cerebrovascular disease were lower than in normal control. The results showed that imbalance of TXA2-PGI2 was closely associated with acute cerebrovascular disease and the level of TXB2 was correlated with the severity of clinical symptom. TXA2 may play a role in the interaction between cerebrovascular disease and IHD.