恶性滋养细胞肿瘤140例临床分析

The Malignant Trophoblastic Tumors: Clinical Analysis of 140 Cases

19715年1月至1985年12月共治疗恶性滋养细胞肿瘤140例,其中绒毛膜癌(简称绒癌)54例(Ⅰ期5例,Ⅱ期8例,Ⅲ期36例,Ⅳ期5例),恶性葡萄胎(简称恶葡)86例(Ⅰ期26例,Ⅱ期12例,Ⅲ期44例,Ⅳ期4例)。采用以化疗为主的综合疗法。随访率为92.86％。治愈好转率绒癌为85.18％,恶葡为98.83％。本文讨论了药物剂量及疗程,预防及减少并发症的措施,手术的适应证及临床分期与预后的关系。

From Jan. 1975-Dec. 1985, 140 patients with malignant trophoblastic tumors were admitted to our hospital, of them 54 were ill with choriocarcinoma (5 cases in stage I, 8 cases in stage Ⅰ , 36 cases in stage Ⅰ, 5 cases in stage Ⅳ) and 86 ill with malignant mole(26 cases in stage Ⅰ,12 cases in stage Ⅰ, 44 cases in stage Ⅰ,4 cases in stage Ⅳ. All patients were initially treated with chemotherapy. Hysterectomy was performed when necessary. The cure and improvement rate of choriocarcinoma was 85.18%, that of malignant mole was 98.83%. The therapeutic dosage and course, the way of preventing and reducing chemotherapeutic complications, and the relationship between the operative indication, clinical staging and prognosis were discussed in this paper.