摘要
为进一步确定神经氨酸酶(NM)的致急性肾炎贫血作用,本文在体外将纯化NM加入人外周血红细胞(RBC)悬液中进行培养。结果RBC逐渐出现变形和溶血;并发现该溶血过程需血清补体系统参与;肝素具有抑制和减缓NM诱导RBC溶血作用。
NM-induced deformation and hemolysis of human red blood cells(RBC) was observed by incubation of human RBC in vitro with purified NM, and serum complement system was found to take part in this process and heparin was accidentally found to inhibit and defer this NM-inducrd hemolysis. The results suggest that NM may play an important pathogenetic role in APSGN anemia.
出处
《同济医科大学学报》
CSCD
北大核心
1989年第A02期94-96,167,共3页
Acta Universitatis Medicinae Tongji
关键词
急性肾炎
贫血
神经氨酸酶
溶血
acute poststreptococcal glomerulonephritis
anemia
neuramlnidase
sialic acid
heparin
red blood cells
