透明细胞肉瘤的病理诊断与鉴别诊断

Diagnosis of clear cell sarcoma

目的掌握透明细胞肉瘤的临床病理特点及组织学不典型性。方法光镜观察3例透明细胞肉瘤组织形态结合免疫组化染色结果分析。结果女性2例,男性1例,年龄27￣50岁,病变部位主要位于四肢远端。组织学显示,该肿瘤细胞组织形态不典型,特别需要和滑膜肉瘤、上皮样肉瘤、恶性腱鞘巨细胞瘤鉴别。所有病例HMB45和S-100均表达阳性。结论透明细胞肉瘤常发生于20至40岁的中青年,透明细胞肉瘤的病理学特点及鉴别诊断紧密结合临床表现和免疫组化结果。

Objective To study the clinical pathological features and differential diagnosis of clear cell sarcoma.Methos Three cases of clearcellsarcoma wrer investigated by light microscopy and immunohistochemistry.Results The patients were 2 female and Imale,aged from 27-50 years old.thelesionwere mainly located in the distal endofextremities.Histologically ,thetumor cell of clear cell coma showed no typical presenationwhich musthe paid special attention to the diseases include synovialsarcoma,epithelioid sarcoma,mali grantgia-cell tumor of Tendon Sheath.All cases were positivef for HMB45 and S100.Conclusions Clears cell sarco maisad is case which is most commly involved in youngpeo ple.20-40 years old.By combining with pathological features and differential diagnosis ,we discuss some points to the diagnosis of clear cell sarcoma.