短肠综合征患者血清游离氨基酸水平的改变

Peripheral amino acid level in patients with short bowel syndrome

目的研究短肠综合征患者血清游离氨基酸水平的变化规律,指导短肠患者的营养支持。方法对17例短肠综合征患者于入院时检测17种血游离氨基酸水平,并选择15例健康志愿者为对照组。结果 17种氨基酸中,短肠综合征患者血清缬氨酸、亮氨酸、异亮氨酸、赖氨酸、蛋氨酸、丝氨酸、胱氨酸、组氨酸水平显著低于对照组(P<0．05),短肠综合征患者支链氨基酸水平(381± 124)μmol／L、必需氨基酸水平(1895±460)μmol/L及必需氨基酸／非必需氨基酸比值(0．4±0．1)均显著低于对照组(P<0．05)。结论短肠综合征患者氨基酸及必需氨基酸均缺乏,在营养支持时需增加必需氨基酸的给予。

Objective To study the alterations of serum amino acid level in patients with short bowel syndrome（SBS）. Methods Blood levels of 17 amino acids were measured in 17 SBS patients on admission to the hospital, and 15 healthy volunteers. Results Compared with the control group, serum concentrations of Val, Leu, Ile, Lys, Met, Set, His, Cys in patients with SBS significantly decreased （P 〈 0.05）, with decreased branch chain amino acid （BCAA） （381 ± 124） μmoL/L, essential amino acid （EAA） （1895 ± 460） μmoL/L, and the ratio of essential amino acid over nonessential amino acid （EAA/NEAA） （ 0.4 ± 0.1 ） （ all P 〈 0. 05 ）. Conclusions Patients with short bowel syndrome suffer from decreased level of serum amino acids and essential amino acids. Extra supplement of essential amino acids is necessary in the nutritional support of these patients.