摘要
采用傅里叶变换红外光谱仪测定6种氨噻肟类头孢菌素约物的红外光谱,讨论了其红外光谱特征与结构的关 系。分析结果表明氨噻肟孢菌素分子结构C3位上的不同取代基对分子光谱有着极大的影响,引起红外光谱中β-内酰胺和 仲酰胺基团羰基特征峰位移的改变,通过分析氨噻肟类头孢菌素药物的红外光谱图中氨基和羰基特征峰的位移和峰形,及具 有特征性的基团振动吸收峰,可以快速、准确、简便鉴别氨噻肟类头孢菌素药物。
Six kinds of cephalosprin were measured with fourier transform infrared spectroscopy and the relations of their structures and spectra were studied. The results show that the vibration frequencies of amide carbonyl are due to the functional groups on C3. The position and shapes of the IR bands of amine, carbonyl and other distinctive groups on six kinds of cephalosporins could be used in pharmaceutical identification. FT - IR method is a rapid and reliable way on identification of different chemical compound.
出处
《广州化工》
CAS
2005年第6期49-50,66,共3页
GuangZhou Chemical Industry
