摘要
目的:测定鸟嘌呤类抗病毒药物油/水分配系数并将实验值与理论计算值进行比较。方法:用 HPLC 法测定,以乙腈-水(5:95)含0.1%的三乙胺和0.1%醋酸,pH 为4~5的溶液系统为流动相,流速:1 mL·min^(-1)。并用碎片常数阐述此类药物油/水分配系数与其药物结构的关系。结果:被测量的化合物误差均小于10%。结论:实验结果符合目前用 HPLC 法测定 logP值所允许的误差范围。
Objective:To determine the O/W partition coefficients (logP) of guanine antiviral agents. And the experimental results were compared with the theoretical values. Method:The HPLC method was applied with the mobile phase consisting of acetonitrile - aqueous solution (500 mL water + 0. 5 mL triethylamine + 0. 5 mL acetic acid, pH = 4 - 5 ) ( 5: 95 ), the flow rate was 1.0 mL · min^- 1. The correlation between the logP and structure of the medicine was detailed with the fragme range ( 10% ). Conclusion: The results ntal constant. Results:The errors of measurement are within the logP error determined by HPLC conform to the popular standard.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2005年第12期1570-1573,共4页
Chinese Journal of Pharmaceutical Analysis