益钙宁、多瑞吉治疗骨质疏松重度骨痛57例临床观察

CLINICAL USE OF ELCITONIN PLUS DUROGESIC TO TREAT OSTEOPOROSIS PAIN

目的观察益钙宁(依降钙素)以及益钙宁和多瑞吉合用治疗骨质疏松急性爆发性骨痛的镇痛效果。方法57例老年骨质疏松爆发性骨痛患者,年龄58~92岁,平均为67.4岁,疼痛强度VAS评分为9.0±0.4,疼痛持续时间为3~8天。A组采用益钙宁20U肌肉注射,2次/W;B组益钙宁20U肌注,2次/W+多瑞吉1.25mg^2.5mg/72h。每3天评估VAS评分及临床症状、体征一次。结果两组治疗前后VAS相比均有明显差异(P<0.01),且B组出现镇痛效果早于A组。结论对急性爆发性骨痛益钙宁、辅以小剂量多瑞吉能更快速缓解疼痛。

Objective： To observe the analgesic effect of eleitonin and eleitonin plus durogesie on urgent bone pain due to osteoporosis. Methods： 57 patients aged 58 -92 years （averaged 67.4 years） were employed in this study. The VAS was 9.0 ±0. 4, and pain duration was 3 - 8 days. Group A ： eleitonin 20U i. m. , twice per week. Group B ： A ＋ durogesie （ 1.25 - 2.5mg/72h）. VAS and physical functions were assessed every 3 days. Results： There was significant difference in the therapeutic effect between preand post-treatment for both groups （P 〈 0.01 ）. Eleitonin plus durogesie produced pain relief earlier than eleitonin alone. Conclusion： Eleitonin combined with durogesie can effectively and quickly relieve urgent bone pain related to osteoporosis.