二甲双胍治疗老年2型糖尿病的疗效及安全性观察

Efficacy and Safety of Metformin in Treatment of Ageing with Type 2D iabetes Mellitus

目的:观察老年2型糖尿病患者使用二甲双胍的疗效与安全性。方法:选取42例,服用磺脲类降糖药物效果不佳的老年2型糖尿病患者加用二甲双胍口服治疗。在治疗随访的24周中,监测空腹血糖、糖化血红蛋白、胰岛素及血脂,并观察药物不良反应。结果:治疗4周后空腹血糖、糖化血红蛋白显著下降,12周后总胆固醇(TC)、低密度脂蛋白(LDL)及甘油三酯(TG)显著下降,24周后高密度脂蛋白(HDL)升高,但血胰岛素无显著变化;23.8%的患者服用二甲双胍后出现恶心、腹泻,但症状轻微且短暂。结论:二甲双胍是治疗老年2型糖尿病安全、有效的药物。

Objective： To assesse the efficacy and safety of metformin in treating type 2 diabetes in the elderly. Methods： Metformin was added in 42 elderly patients with type 2 diabetes mellitus poorly controlled with sulphonylurea. Plasma glucose, insulin, glocosylated hemoglobin, lipid, and the side effects were monitored during a follow- up period lasting 24 weeks. Results： The levels of fasting plasma glucose and hemoglobin A1 significantly reduced 4 weeks after treatment, and The levels of plasma LDL and TG 12 weeks after the treatment; but HDL increased 24 weeks after the treatment. Plasma insulin had no significant change during 24 weeks of the treatment. Nausea and diarrhea were more common （23.8%）, but these symptoms were mild and transient. Conclusion： Metformin is an effective and safe drug in the treatment of ageing patients with type 2 diabetes millitus.