还原型谷胱甘肽治疗非酒精性脂肪肝40例

Effect of Reduced Glutathione in Treatment of Non-alcoholic Fatty Liver Disease

目的:观察还原型谷胱甘肽(GSH)治疗非酒精性脂肪肝的临床疗效。方法:80例患者随机分成两组,治疗组(40例)予0.9%氯化钠注射液250mL+GSH1200mg静脉滴注,对照组(40例)予0.9%氯化钠注射液250mL+维生素C2000mg静脉滴注,均每日1次,连用3～4周,分别比较两组用药后的肝功能指标变化情况。结果:治疗组治疗后,肝功能指标均明显降低,较治疗前差异显著;治疗组和对照组肝功能改善的总有效率分别为87.5%和30.0%,两组差异非常显著(P<0.01)。结论:GSH治疗非酒精性脂肪肝疗效显著,且用药安全。

Objective： To assess the effect of reduced glutathione（GSH）on non-alcoholic fatty liver disease, Methods： 80 patients with non-alcoholic fatty liver disease were divided into two groups randomly, the treatment group（40 patients）received GSH 1 200 mg intravenously per day for 3 ～4 weeks and the control group（40 patients）received vitamin C 2000 mg intravenously per day for 3～4 weeks, The changes of liver function in the two groups were compared, Results： The levels of serum ALT, AST, γ- GT in the treatment group were all obviously reduced at the end point compared with the baseline. The levels of serum ALT in the control group was reduced, but the levels ofserum AST, r- GT were no obviously changed, The total effective rate of the treatment group and the control group were 87.5% and 30, 0% ,respeclively（P〈0. 01）. Conclusion： GSH is an effective and safe remedy for the treatment of non- alcoholic fatty liver disease,