从胆酸制备的牙科树脂溶胀性能研究

Sweling and Wettability of Light-Cured Methacrylate-Based Dental Resins Prepared from Cholic Acid

从胆酸(CA)合成了2’-甲基丙烯酰氧基乙基-3α,7α,12α-三甲基丙烯酰氧基-5β-胆酸 -24-酯(CACE4MA),并应用光聚合方法将其制成了高分子树脂。实验选用商业单体2,2’-二 [4-(2-羟基-3-甲基丙烯酰氧丙氧基)苯基]丙烷(Bis—GMA)作为对比物,三甘醇二甲基丙烯酸酯(TEGDMA)作稀释剂,樟脑醌(CQ)和甲基丙烯酸-2-(二甲氨基)乙酯(DMAEMA)的混合物作引发剂。研究光照时间为60 s的树脂在蒸馏水和0．1 mol／L HCl溶液中的溶胀行为。研究显示,在蒸馏水中CAGE4MA树脂的溶胀值是0．41％,比相同条件下商业单体Bis—GMA (2．04％)和TEGDMA(4．77％)的溶胀值低。CAGE4MA和TEGDMA共聚物的溶胀值随着树脂中TEGDMA含量的增加而增加。

2＇-Methacryloyloxyethyl 3α,7α,12α-trimethacryloyloxy -5β-cholan-24-ate （CAGE4MA） has been prepared from cholic acid. Photo-polymeric resins were prepared from CAGE4MA. 2,2-bis [ 4- （2-hydroxy-3-methaerylyloxypropoxy） phenyl propane （ Bis-GMA ） was used for comparison, triethyleneglycol dimethacrylate （TEGDMA） was used as diluent. The polymerization was initiated by camphoroquinone （CQ） / N, N-dimethylaminoethyl methacrylate （DMAEMA） system. The initiated time was 60s. The swelling behaviors of resins in distilled water and 0.1 mol/L HCI solutions were studied. The swelling value of CAGE4MA resin was 0.41% in distilled water, which is much lower than those of bis-GMA resin （2.04%） and TEGDMA resin （4.77%） under the same conditions. Copolymers of CAGE4MA and TEGDMA have been prepared. With the increase of TEGDMA in mixture, the swelling value of CAGE4MA-TEGDMA resins increased.