摘要
目的探讨肽YY3鄄36穴PYY3鄄36雪、胰升糖素样肽鄄17鄄36(GLP鄄17鄄36)联合及单独用药对食欲和血糖的影响。方法健康志愿者行双盲对照,分别注射盐水(saline)、PYY3鄄36、GLP鄄17鄄36、PYY3鄄36+GLP鄄17鄄36,观察其能量摄入情况。留取血样测定肽YY(PYY)、胰升糖素样肽鄄1(GLP鄄1)、葡萄糖、胰岛素。结果同盐水组比较,PYY3鄄36+GLP鄄17鄄36组、PYY3鄄36组及GLP鄄17鄄36组摄取食物能量明显减少(对能量摄取与盐水组相比较,其百分比依次为PYY3鄄36+GLP鄄17鄄36(鄄28±2%),PYY3鄄36(鄄15±6%),GLP鄄17鄄36(鄄5±5%);在PYY3鄄36+GLP鄄17鄄36组、PYY3鄄36组PYY浓度增加,GLP鄄17鄄36组下降。PYY3鄄36+GLP鄄17鄄36组、GLP鄄17鄄36组GLP鄄1浓度增加,PYY3鄄36组无明显变化;在GLP鄄17鄄36组、PYY3鄄36+GLP鄄17鄄36组输入90min时胰岛素浓度增加,PYY3鄄36组无明显变化。GLP鄄17鄄36组、PYY3鄄36+GLP鄄17鄄36组输入90min时血糖浓度降低,PYY3鄄36组无明显变化。结论PYY3鄄36+GLP鄄17鄄36有明显抑制食欲作用熏其程度依次高于PYY3鄄36、GLP鄄17鄄36,且PYY3鄄36+GLP鄄17鄄36及GLP鄄17鄄36能降低血糖。
Objective To investigate the effects of peptide YY3-36 （PYY3-36） and glucagon-like peptide-1 （GLP-17-36） infusion in health people. Methods Ten volunteers were divided into four groups and injected respectively with saline, GLP-17-36 PYY3-36 or PYY3-36＋ GLP-17-36. Energy expenditures were measured before and after a free buffet lunch. Blood samples were obtained for the content analysis of PYY, GLP-1, Glucose and Insulin. Results （1）Combined with the saline group, the daily food intake was decreased by 28±2% in PYY3-36＋GLP-17-36 group, 15±6% in PYY3-36 and 5±5% in GLP-17-36; （2）There were significant increases in plasma PYY levels with PYY3-36 and PYY3-36 ＋ GLP-17-36 infusions, and GLP-1 levels with GLP-17-36 and PYY3-36 ＋GLP-17-36 infusions; （3） Plasma insulin was increased and glucose was reduced by GLP-17-36 infusion at 90 minutes compared with saline but not changed with PYY3-36 alone. The co-administration PYY3-36 ＋ GLP-17-36 infusion enhanced insulin secretion, but there was no additional secretion compared that with GLP-17-36 alone. Conclusion Energy intakes were significantly lower with PYY3-36＋GLP-17-36 application, and PYY3-36 and GLP- 17-36 in turn. Blood glucose was reduced with PYY3-36＋GLP- 1 7-36 and GLP- 17-36.
出处
《中国慢性病预防与控制》
CAS
2005年第6期292-294,共3页
Chinese Journal of Prevention and Control of Chronic Diseases
