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2型糖尿病易感基因研究进展 被引量:3

The Research Advance in the Susceptibility Genes of the Type 2 Diabetes Mellitus
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出处 《中国慢性病预防与控制》 CAS 2005年第6期310-312,共3页 Chinese Journal of Prevention and Control of Chronic Diseases
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  • 1Gu HF, Almgren P, Lindholm E, et al . Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis [J] . Diabetes, 2000,49 : 1601 .
  • 2Tschritter O, Stumvol M, Machicao F, et al. The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (Kir6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia [J]. Diabetes, 2002,51: 2854.
  • 3Deeb SS , Fajas L, Nemoto M , et al . A Pro12Ala substitution in PPAR-γ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity [J]. Nat Genet,1998,20:284-287.
  • 4Altshuler D , Hirschhorn J N , Klannemark M , et al . The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J]. Nat Genet, 2000,26 : 76-80.
  • 5Jellema A, Zeegers MP, Feskens EJ, et al, Gly972Arg variant in the insulin receptor substrate-1 gene and association with type 2 diabetes :a meta-analysis of 27 studies [J].Diabetologia, 2003,46 : 990-995.
  • 6Triggs-Raine BL , Kirkpatrick RD , Kelly SL , et al . HNF-1alpha G319S, atransactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community [J]. Proc Natl Acad Sci. 2002,99 : 4614-4619.
  • 7Mohlke KL, Silander K , Peck EC , et al . Common non-coding SNPs near the Hepatocyte Nuclear Factor-4 Alpha gene are associated with type 2 diabetes [J].Am J Hum Genet, 2003,73 : 210.
  • 8Love-Gregory L, Wasson J, Ma J, et al . A common polymorphism in the upstream promoter (P2) of the HNF 4 alpha gene on chromosome 20q is associated with type 2 diabetes (T2DM) and appears to account for the evidence for linkage in an Ashkenazi Jewish population [J]. Am J Hum Genet, 2003,73 : 534.
  • 9Hani EH, Stoffers DA, Chevre JC , et al. Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus [J].J Clin Invest, 1999,104 : R41-48.
  • 10Macfarlane W, Frayling T, Ellard S, et al. Missense mutations in the insulin promoter factor 1 (IPF-1) gene predispose to type 2 diabetes[J]. J Clin Invest, 1999,104 : R33-R39.

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