摘要
对注射用盐酸阿糖胞苷采用旋光法进行测定,测定管长为1 cm.当盐酸阿糖胞苷浓度在1～9.000 0 g·L-1之间时,旋光度与浓度呈线性关系,回归方程为a=0.130 1 C+0.000 1,相关系数为0.999 9,平均回收率为99.93%,RSD为0.47%.方法简便、快速、准确,适合于药厂、医院对产品及制剂的快速分析.
Polarimetry was applied to the determination of content of cytarabinehydrochloride in injections. Degree of optical rotation of the drug was determined with polarized light of 589.3 nm passing through a measuring tube with 1 cm in light path. Experimental results showed that linear relationship between the measured signal and concentration of cytarabine hydrochloride was kept in the range from 1 to 9. 000 0 g · L^-1, with the following linear regression equation： α=0. 130 1 C＋0. 000 1 （r=0. 999 9）, Results of recovery test gave an average recovery of 99. 93% and a RSD （n= 6） of 0.47%, In its application to the analysis of injection samples of different hatches, results obtained by this method were in conformity with these obtained by the pharmacopoeia method of UVspectrometry.
出处
《理化检验（化学分册）》
CAS
CSCD
北大核心
2005年第12期910-911,共2页
Physical Testing and Chemical Analysis(Part B:Chemical Analysis)
基金
国家教育部高等学校访问学者基金资助项目
关键词
旋光法
注射用盐酸阿糖胞苷
测定
Polarimetry
Cytarabine hydrochloride injection
Determination
