150例女性下生殖道尖锐湿疣的临床病理和实验室分析

Condyloma acuminatum of lower birth canal:Clinical,pathological and laboratory analysis of 150 cases.

本文对１５０例女性下生殖道尖锐湿疣病人，从临床、病理和实验室方面进行研究。尤其是应用ＰＣＲ方法，对患者的宫颈细胞、局部病灶进行ＨＰＶ—ＤＮＡ的检测，证实女性ＨＰＶ感染好发于性活跃人群，性传播为主要方式，常重叠感染其它ＳＴＤ。病理学对结节菜花型病灶者的诊断可达９７．６％；对簇状粟粒型病灶的诊断仅为５０％，而其余病人用ＰＣＲ检测ＨＰＶ－ＤＮＡ５５％～５９％阳性，证明有ＨＰＶ感染．用ＰＣＲ方法对患者的宫颈脱落细胞和局部病灶同时检测发现，外阴部位的ＨＰＶ感染，几乎同时伴有宫颈和阴道的ＨＰＶ感染。同时还提示ＰＣＲ方法在对ＨＰＶ的检测方面是敏感特异的方法。

bjective: To study the diagnostic value of clinical,pathologlcal and PCR method on the women withHPV. Design: 150 patients with condyloma acuminaturn treated between 1992 and 1993 at Beijing Friendship Hospital were reviewed and the clinical history,exfoliated cervical cells and the focus were collectedfor the pathological and PCR diagnosis. Results: Theage of the women with HPV were between 20 and 39.97. 6%o f nodose focus were diagnosed by pathology.The cervical cells and focus examination by PCRshowed that almost all the HPV infections of vulvaewere accompanied by the vaginal and cervical infection. The pathology negative patients were tested byPCR and 50% - 55% of them showed HPV-DNApositive. Conclusion: The diagnosis of HPV infectionin women should rely on the clinical and pathologicalexamination and PCR test. The pathology negative patients should be given the PCR test for further diagnosis.