银杏达莫注射液对椎基底动脉系统短暂性脑缺血发作患者血液流变学的影响

Effect of Yinxingdamo Injection on Hemorrheology in Patients with Vertebrobasilar Transient Ischemic Attack

目的比较银杏达莫注射液与复方丹参注射液对椎基底动脉系统短暂性脑缺血发作（TIA）患者血液流变学的影响。方法68例椎基底动脉系统TIA患者分为治疗组38例和对照组30例。治疗组给予银杏迭莫注射液20mL，对照组给予复方丹参注射液30-50mL，两药分别加入0．9％氯化钠注射液或5％葡萄糖注射液500mL中，静脉滴注，qd，连续14d。检测治疗前及治疗14d后血液流变学指标。结果治疗组在治疗后低切全血黏度明显降低（P〈0.05），红细胞变形性显著增高，血细胞比容、红细胞聚集指数和血小板聚集率均显著下降，治疗前后比较差异有极显著性（P〈0．01）。对低切全血黏度的下降和红细胞变形性升高幅度，治疗组显著高于对照组（P〈0.05）。对红细胞比容，红细胞聚集指数和血小板聚集率的下降作用，治疗组优于对照组（P〈0．01）。结论银杏达莫注射液可显著地降低椎基底动脉系统TIA患者全血黏度、红细胞比容、红细胞聚集指数、血小板聚集率和增加红细胞变形性，作用明显优于复方丹参注射液。

Objective To compare the effects of yinxingdamo injection with compound salvia mihiorrhiza injection on hemorrheology in patients with vertebrobasilar transient ischemic attack （TIA）. Methods Sixty-eight patients with vertebrobasilar TIA were randomly divided into two groups, the treatment group （n = 38 ）and the control group （n = 30）. Patients in the treatment group were given yinxingdamo injection 20 mL, iv drip, qd, patients in the control group were given compound salvia miltiorrhiza injection 30 - 50 mL, iv drip, qd. Before and 14 days after the treatment, the changes in hemorrheology were observed. Results In the treatment group after treatment the low shear value of the whole blood viscosity decreased markedly （ P 〈 0.05 ）, erythrocyte deformability increased apparently, and erythrocyte packed ceil volume, erythrocyte aggregation rate, platelet aggregation rate decreased markedly （ P 〈 0.01 ）. As to the decrease in whole blood viscosity and amplitude in the increase of erythrocyte deformity, the treatment group was significantly greater than the control group （ P 〈 0.05 ）, and for the decrease in erythrocyte packed cell volume, erythrocyte aggregation rate and platclet aggregation rate, the treatment group was superior to the control group（ P 〈 0.01 ） . Conclusion Yinxingdamo injection can improve the hemorrheology in patients with vertebrobasilar TIA with an effect superior to compound salvia miltiorrhiza.