盐酸戊乙奎醚和东莨菪碱用于法洛四联症患者手术前的效果比较

Clinical Comparision of Penehyclidine Hydrochloride and Scopolamine on Premedication in Patients with Tetralogy of Fallot.

目的比较抗胆碱药盐酸戊乙奎醚和东莨菪碱用于法洛四联症患者于术前的临床效果。方法将40例ASAⅡ的法洛四联症患者随机分为盐酸戊乙奎醚组(W组)和东莨菪碱组(D组),每组20例。D组患者术前30 m in肌内注射吗啡0.2 mg.kg-1和东莨菪碱0.01 mg.kg-1(总量≤0.3 mg),W组患者术前30 m in肌内注射吗啡0.2mg.kg-1和盐酸戊乙奎醚0.02 mg.kg-1(总量≤1 mg),记录患者给药前、给药后15 m in、麻醉诱导前、锯胸骨、体外循环(CPB)建立前的心率(HR)、脉搏氧饱和度(SPO2)。结果术前给药后至麻醉诱导前,与D组比较,W组HR明显减慢(P<0.05),SPO2明显较高(P<0.05)。结论盐酸戊乙奎醚用作法洛四联症患者术前抗胆碱药比东莨菪碱效果更好。

Objective To compare the effects of penehyclidine hydrochloride and scopolamine used as premedication in patients with tetralogy of Fallot . Methods Forty ASAⅡ patients with tetralogy of Fallot were randomly divided into two groups, the penehyclidine hydrochloride group （group W, n = 20） and the scopolamine group（ group D, n = 20 ）. All patients were administered drugs 30 min before operation. Patients of the group W were given penehyclidine hydrochloride 0. 02 mg·kg^-1 （ the total amount no more than lmg） plus morphine 0. 2 mg·kg^-1 and patients of the group D were given scopolamine 0. 01 mg·kg^-1, （the total amount no more than 0. 3 mg）plus morphine 0. 2 mg·kg^-1. Heart rate （HR） and pulse oximeter oxygen saturation （SPO2 ） were recorded at the time before the injection of premedication, 15 min after premedication,before induction, sternotomy and before establishing cardiopulmonary bypass （CPB）. Results During the time after the injection of premedication to before induction, compared with the patients of group D, HR was significantly slower （ P 〈0. 05 ） and SPO2 was significantly higher（ P 〈 0 .05） in the patients of group W. Conclusion Used as premedication, penehyclidine hydrochloride is better than scopolamine in patients with tetralogy of Fallot.