家兔脊髓空洞症致脊柱侧弯发生的机制

Mechanism of scoliosis induced by experimental syringomyelia in rabbits

目的探讨实验性脊髓空洞症致脊柱侧弯发病机制。方法24只中国白兔，其中12只制作脊髓空洞模型，另12只作对照。定期MR扫描，拍脊柱正侧位片判断侧弯程度，并用光镜观察脊髓和椎旁肌肉标本。结果4～6周时，9只动物中8只出现脊髓空洞，6只出现颈胸段脊柱侧弯；8周以后，空洞随观察时间延长而逐渐增大、受累节段增多，同时脊柱侧弯程度也明显加重。椎旁肌肉出现代表神经源性变性的小角纤维。结论实验性脊髓空洞症常引起脊柱侧弯，脊柱侧弯加速脊髓空洞发展。及早终止两者的恶性循环将有助于改善本病的预后。

Objective To investigate the mechanism of scoliosis induced by experimental syringomyelia in rabbits. Methods Experimental syringomyelia models were induced in 12 Chinese white rabbits and 12 served as controls. MRI imaging was performed at a regular interval on all animals after operation. X-rays graph was used to determine the degree of rabbits＇ scoliosis and light microscopy was employed to observe spinal cord and para-spinal muscle. Results At 4-6 weeks, 8 of 9 animals in Kaolin group developed syringomyelia, and 6 of 9 suffered scoliosis. Eight weeks later, scoliosis developed with experimental syringomyelia and its severity aggravated as the involving spinal cord segments of experimental syringomyelia increased. Light microscopy showed small angular fibers representing neurogenic changes. Conclusion Scoliosis develops with experimental syringomyelia and promotes syringomyelia deterioration. Terminating this vicious circle at early stage may be helpful to improve the prognosis of these disorders.