股动脉外膜交感神经网剥脱切除对骨内高压神经肽的影响

Effect on neuropeptide in intraosseous hypertension after sympathectomy on the membrane of arteria femoralis in rabbits

目的探讨股动脉外膜交感神经网剥脱切除对骨内高压的影响。方法30只新西兰纯种大白兔制作成右胫骨上端骨内高压模型,随机分为对照组和实验组,实验组行右股动脉外膜交感神经网剥脱切除术,测量手术前、后两组骨内压及手术后骨髓血中神经肽的改变。结果手术后实验组骨内压值下降明显(P<0.05),对照组与实验组术后神经肽Y(NPY)由(15.32±7.63)ng/L下降至(14.26±8.23)ng/L(P>0.05),降钙素基因相关肽(CGRP)由(25.76±4.97)ng/L上升至(33.89±9.63)ng/L(P<0.05)。结论股动脉外膜交感神经网剥脱切除后,血管扩张,骨内压下降。

Objective To explore the effect of sympathectomy on the membrane of arteria femoralis on intraosseous hypertension in rabbits. Methods The model of intraosseous hypertension was established in 30 experimental rabbits. The rabbits were divided into experimental group and control group. The sympathectomy on the membrane of arteria femoralis was carried out in experimental group. The intraossseous pressure was measured in the experimental and control group before and after operation. NPY and CGRP were measured in experimental and control group after operation. Results NPY in control group and experiment group was decreased from （15.32 ± 7.63） ng/L to （14.26 ± 8.23） ng/L （P〉0.05）, while CGRP was increased from （25.76± 4.97） ng/L to （33.89±9.63） ng/L （P〈 0.05）. Conclusion The blood vessel is dilated and the intraosseous pressure decreased after sympathectomy on the membrane of arteria femoralis.