一种生物陶瓷体内血管化动物模型的建立

An establishment of a new vascularized animal-model in vivo with bioceramics

目的建立一种新的生物陶瓷（Bioceramics）体内血管化动物模型。方法选择体重2．5～3kg的成年新西兰兔24只进行动物手术，在生物陶瓷人工骨的中轴穿入兔腰背动脉后将其包埋入兔左侧腰背筋膜内，将其作为实验组，右侧单纯埋入生物陶瓷作为对照组。术后4周、8周、12周后对人工骨材料进行切片染色、骨扫描等检查，观察人工骨血管化及骨代谢情况。结果术后4周实验组人工骨材料内出现发育成熟的血管，并开始出现新生骨和骨代谢，术后12周骨小梁发育成熟，而对照组血管化及骨化程度较差。结论中轴穿入动脉的人工骨材料埋入兔腰背筋膜后可以显著地促进人工骨的血管化。

Objective To establish a new vascularized animal-model with bioceramics. Methods Twenty-four adult rabbits were selected for operation. An artery lumbodorsalis was put into central axis of the artificial bone and implanting the artificial bone into every rabbit＇s left fascia lumbodorsalis for experiment group, and put pure artificial bone into every rabbit＇s right fascia lumbodorsalis for control group. The samples were take out for section-staining and bone scanning after 4, 8 and 12 weeks. Results In experiment group, there were mature blood vessels, and newly formed bone appeared after 4 weeks and bone trabecula came into mature after 12 weeks. Conclusion Putting an artery into central axis of the artificial bone and implanting the artificial bone into rabbit＇s fascia lumbodorsalis can notably improve vascularization and bone metabolism of the artificial bone.