胃泌素在婴幼儿肠套叠发病中的作用

Theroleofhypergastrinemiainthepathogenesisofintususceptionininfants

为探讨婴幼儿肠套叠的发病机理，作者测定了１２４例次肠套叠婴幼儿、１５例小肠梗阻患儿及２０例同龄正常婴幼儿血清胃泌素值及ｃＡＭＰ值。在动物实验中，测定了５－肽胃泌素对幼犬回肠蠕动频率及回盲瓣压力的影响。结果显示，患儿血清胃泌素值及ｃＡＭＰ值显著高于正常对照组（Ｐ＜０．０１，Ｐ＜０．０５）。５－肽胃泌素对加快回肠蠕动及松弛回盲瓣的影响与肠套叠的基本病理一致。作者提出高胃泌素血症是婴幼儿肠套叠发病的主要因素。

From1988to1992theserumgastrinlevelsof124patientswithintussusceptionand20normalinfantsand15patientswithintestinalobstructionunder3yearsofageweremeasured.SerumcAMPlevelsof10normalinfantsand10patientswithintussusceptionweredetermined.Inanimalex-perimentstudy,thepressuresofileumcavityandileocealvalveweredeterminedbeforeandafterinject-tingpentagastrinintotheveinsof8youngdogs.Thelevelsofgastrin(219.9±100.6pg/ml)andcAMP(32.4±7.6pmol/ml)werehigherinpatientgroupthaninthecontrolgroup.(89±3pg/ml,P<0.05and22.2±7.5pmol/mlP<0.05).Theresultofanimalexperimentshowedthattheeffectofgastrinandetiologyofintussusceptionareidentical.Themainphysiologicalfuncitonsofgastrinistoincreasethein-testinalperistalsisandrelaxtheileocecalsphincter.Ourstudyshowedthathypergastrinemiamaybethebasisetiologicfactorofintussusception.Mainclinicalfeactureswereexplainedbythisnewtheory.