表皮生长因子和原癌基因c－myc在银屑病皮损中的异常表达

Study on over-expression of epidermal growth factor and oncopene c-myc in psoriatic keratinocytes

表皮生长因子是强有力的促角朊细胞分裂剂，可以诱导原癌基因ｃ－ｍｙｃ的表达，而ｃ－ｍｙｃ又是调控细胞增殖的主要基因。应用免疫组化ＳＰ法对３０例银屑病和１２例正常对照组中的表皮生长因子和ｃ－ｍｙｃ的表达进行研究。结果显示ＥＧＦ和ｃ－ｍｙｃ在银屑病皮损中的异常表达，与正常人相比经统计学处理有显著性差异；银屑病皮损的严重程度与角朊细胞中ＥＧＦ和ｃ－ｍｙｃ和表达水平有明显相关性。

Epidermal growth factor(EGF)is a potent mitogen of keratinocytes,it can induce the expression of pro-oncogene c-myc.Oncogene c-myc is the major gene for regulation of cell proliferation.Immunohistochemical study was carried out for EGF and c-myc in keratinocytes from 30 patients with psoriasis and 12 normal control. The results showed that expression of EGF and c-myc in lesions of psoriatic patients was significantly higher than that in normal control,and incresed level correlated with severity of the lesions.