特发性血小板减少性紫癜与HCMV活动性感染

Study of active cytomegalovirus infection in children with immune thrombocytopenic purpura

用间接ＥＬＩＳＡ法对３８例临床确诊为特发性血小板减少性紫癜（ＩＴＰ）患儿和３１例健康儿童血浆（血清）进行人巨细胞病毒（ＨＣＭＶ）ＩｇＧ、ＩｇＭ检测，其中３０例患儿同时进行了血灰黄层白细胞病毒分离。结果：ＩＴＰ患儿中有１５例检出高效价ＨＣＭＶＩｇＧ，阳性率为３９．４７％；有６名检出ＨＣＭＶＩｇＭ，阳性率为１５．７９％；健康儿童中高效价ＨＣＭＶＩｇＧ检出者仅２例，阳性率为６．４５％；ＨＣＭＶＩｇＭ均为阴性。经统计学处理两组ＩｇＧ差异有高度显著性，说明ＩＴＰ患儿有ＨＣＭＶ活动性感染且可能是ＩＴＰ反复发作的重要原因之一。提示对ＩＴＰ患儿进行ＨＣＭＶ活动性感染的检测，可为临床预测、诊断及治疗提供有价值的参考依据。

Human cytomegalovirus (HCMV) IgG,IgM antibodies were detected with ELISA in 69 serum specimens from 38 children with immune thrombocytopenic purpura(ITP) and 31 children of normal controls. HCMV isolates from 30 leucocytes specimens with ITP were also studied. The results showed that positive rate of IgG and lgM of ITP children was 39. 47% and 15. 79% respectively, and that of normal controls was 6. 45% and negative respectively. IgG showed significant difference between two groups, indicating that children of active HCMV infection with ITP might have a relapse. The detection was valuable in clinical prognosia, analysis of condition, observation of theraputic effects for ITP children.