期刊文献+

PP2A在细胞凋亡中的作用 被引量:2

下载PDF
导出
摘要 细胞内信号转导途径控制着细胞的生长、发育、代谢、转化和凋亡等许多生理过程,而控制这些途径的重要机制是由蛋白激酶和磷酸酶共同调节的蛋白可逆性磷酸化.相对于蛋白激酶,目前蛋白磷酸酶作用通路研究并不是很清楚.
出处 《医学研究通讯》 2005年第11期58-59,共2页 Bulletin of Medical Research
基金 国家自然科学基金(30271540)资助
  • 相关文献

参考文献6

  • 1Silverstein AM, Barrow CA, Davis AJ, Mumby MC.Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits.Proc Natl Acad Sci US A, 2002 Apt 2, 99 (7): 4221 -4226.
  • 2Klunrpp S, Krieglstein J.Sefine/threonine protein phosphatases in apoptosis. Curr Opin Pharmacol.2002 Aug, 2 (4) : 458-462.
  • 3Ruvolo PP, Clark W, Mumby M, et al. A functional role for the B56 alpha- subunit of protein phosphatase 2A in ceramide - mediated regulation of Bcl2 phosphorylation status and function.J Biol Chem.2002 Jun 21, 277(25) : 22847 - 22852.
  • 4Simizu S, Tamura Y, Osada H.Dephosphorylation of Bcl - 2 by protein phosphatase 2A results in apoptosis resistance. Cancer Sci.2004 Mar, 95(3): 266-270.
  • 5Chiang CW, Kanies C, Kim KW, et al.Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD - mediated apoptosis. Mol Cell Biol.2003 Sep, 23 (18) : 6350 - 6362.
  • 6Silverstein A.M., Barrow C.A., Davis A.J..Actions of PP2A on the MAP kinase pathway. PNAS, 2002 April 2, 99 ( 7 ) : 4221 - 4226.

同被引文献12

  • 1SHI Yi Gong Center for Structural Biology, Department of Biological Sciences and Biotechnology, and School of Medicine, Tsinghua University, Beijing 100084, China.Assembly and structure of protein phosphatase 2A[J].Science China(Life Sciences),2009,52(2):135-146. 被引量:13
  • 2冯永庆,秦岭,杨东生,董清华.板栗短雄花序芽变的主要特征特性研究[J].北京农学院学报,2005,20(3):1-5. 被引量:18
  • 3张婧,董清华,杨凯,曹庆芹,冯永庆,秦岭.板栗短雄花序异常死亡的超微结构观察[J].园艺学报,2007,34(3):605-608. 被引量:21
  • 4Chen W, Wang Z, Jiang C, et al. PP2A - Mediated Anticancer Therapy[ J]. Gastroenterol Res Pract, 2013, 2013:675429.
  • 5Arroyo JD, Hahn WC. Involvement of PP2A in viral and cellular transformation [ J ]. Oncogene, 2005,24 (52) :7746-7755.
  • 6Jin Z, Wallace L, Harper SQ, et al. PP2A: B56t epsilon} , a substrate of easpase-3, regulates p53-dependent and p53-inde- pendent apoptosis during development [ J]. J Biol Chem, 2010, 285 (45) :34493-34502.
  • 7Janssens V, Rebono A. The role and therapeutic potential of Set/ Thr phosphatase PP2A in apoptotic signalling networks in human cancer cells[J]. Curr Mol Med, 2012,12(3) :268-287.
  • 8Eichhorn PJ, Creyghton MP, Bernards R. Protein phosphatase 2A regulatory subunits and cancer[ J]. Biochim Biophys Acta, 2009, 1795 ( 1 ) : 1-15.
  • 9Wang Z, Sun Y. Identification and characterization of two splicing variants of human Noxa [ J ]. Anticancer Res, 2008,28 ( 3A ) : 1667-1674.
  • 10王柏婧,魏群.Ser/Thr蛋白磷酸酶PPP家族结构研究新进展[J].中国科学(C辑),2008,38(7):591-598. 被引量:3

引证文献2

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部