耐信治疗胃食道反流病的临床观察

The Clinical Observation of Esomeprazole Treating Gastroesophageal Reflux Disease

目的观察耐信治疗胃食道反流病(GERD)的疗效及副作用。方法对60例胃食道反流性疾病患者随机分成两组,用奥美拉唑作为对照组。治疗组30例每晨服耐信20mg,对照组30例每晨服奥美拉唑20mg,共4周,观察烧心、胸骨后疼痛和反酸首次好转时间、四周完全缓解率、内镜下食道炎愈合率以及安全性、耐受性。结果治疗四周后,症状完全缓解率、内镜下食管炎愈合率、用药后症状首次好转时间两组对比均无统计学意义。结论在治愈和缓解 GERD 患者的症状方面,剂量相同时,耐信有不低于奥美拉唑的疗效且有与奥美拉唑相似的耐受性和安全性。

Objective To observe the efficaey and adverse events of Esomeprazole in treating patients with gastroesophageal reflux disease （GERD）. Methods 60 patients with GERD were randomized to Esomeprazole 20mg （n = 30） and Omeprazole 20mg （n = 30） once daily for 4 - wk, The Omeprazole was considered the eontral group. The efficacy endpoints were healing rate of esophagitis at 4 - wk, time to first resolution and the proportion of complete resolution of symptoms （heartburn, acid - reflux, the pain behind sternum）. Safety and tolerability were also assessed. Results At wk - 4, no statistical significance was found between two groups. Conclusions In cure and symptom relief of the patients with GERD, Esomeprazole demonstrates no less effieaey than Omeprazole. The tolerability and safety of esomeprazole are comparable to that of Omeprazole.