1Hanai J;Dhanabal M;Karumanchi SA.Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1[J],2002(19).
2MacDonald NJ;Shivers WY;Narum DL.Endostatin binds tropomyosin.A potential modulator of the antitumor activtity of endostatin,2001(27).
3Wickstrom SA;Veikkola T;Rehn M.Endostatin-indused modulation of plasminogen activation with concomitant loss of focal adhesions and actin stress fibers in cultured human endothelial cells,2001(17).
4Kreuger J;Matsumoto T;Vanwildemeersch M.Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function[J],2002(23).
5Ramchandran R;Dhanabal M;Volk R.Antiangiogenic activity of restin,NC10 domain of human collagen X Ⅷ:comparison to endostatin[J],1999(03).
6Felbor U;Dreier L;Bryant RA.Secreted cathepsin L generates endostatin from collagen ⅩⅧ,2000(06).
7Dixelius J;Larsson H;Sasaki T.Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis[J],2000(11).
8Wu P;Yonekura H;Li H.Hypoxia down-regulates endostatin production by human microvascular endothelialcells and pericytes,2001(05).
1[3]O'Reilly MS,Boehm T,Shing Y,et al. Endostatin:An endogenous inhibitor of angiogenesis and tumour growth [ J ]. Cell,1997,88(1) :277 - 285.
2[4]Eder JP, Supko JG, Clark JW, et al. Phase I clinical trial of recombinant human endostatin administered as a short intravenous infusion repeated daily[ J ]. J Clin Oncol, 2002,20 (18): 3772 -3784.
3[5]Gehan EA, Teffe MC. Will there be resistance to the RECIST (Response Evaluation Criteria In Solid Tumors)? [J]. J Natl Cancer Inst ,2000,92(3): 179 - 181.
4[6]Yoon SS, Eto H, Lin CM, et al. Mouse endostatin inhibits the formation of lung and liver metastases[ J ]. Cancer Res, 1999,59(24): 6251 - 6256.Chinese Journal of New Drugs 2004,Vol. 13 No. 6
5[7]Yokoyama Y, Dhanabal M, Griffioen AW, et al. Synergy between angiostatin and endostatin: Inhibition of ovarian cancer growth[J]. Cancer Res ,2000,60(8) :2190 - 2196.
6[8]Sim BKL,Fogler WE,Zhou XH, et al. Zinc ligand-disrupted recombinant human endostatin: Potent inhibitions of tumor growth, safety and pharmacokinetic profile [ J ]. Angiogenesis,1999,3(1) :41 - 51.
7[9]Herbst RS,Hess KR,Tran HT, et al. Phase I study of recombinant human endostatin in patients with advanced solid tumors[ J ]. J Clin Onco, 2002,20 (18): 3792 - 3803.
8[10]Thomas JP,Arzoomanian RZ,Alberti D, et al. Phase Ⅰ pharmacokinetic and pharmacodynamic study of recombinant human endostatin in patients with advanced solid tumors[J]. J Clin Onco,2003,21 (2): 223 - 231.
9[1]Sim BK, MacDonald NJ, Gubish ER. Angiostatin and endostatin:Endogenous inhibitors of tumour growth[J]. Cancer Metastasis Rev ,2000,19(1 - 2): 181 - 190.
10[2]Zatterstrom UK, Felbor U, Fukai N, et al. Collagen XVⅢ / endostatin structure and functional role in angiogenesis [ J ]. Cell Struct Funct ,2000,25(1): 97 - 101.
1Huang L,Lu J,Wroblewski VJ,et al.In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.Anal Chem,2005,77(5):1432-1439.
2Takata T,Woodbury LG,Lampi KJ.Dcamidation alters interactions of beta-erystallins in hetero-oligomers.Mol Vis,2009,15:24l-249.
3Liu YD,van Enk JZ,Flynn GC.Human antibody Fc deamidation in vivo.Biologicals,2009,37(5):313-322.
4Wright HT.Nonenzymatic deamidation of asparaginyl and glutaminyl residues in proteins.Crit Rev Biochem Mol Biol,1991,26(1)1-52.
5Tyler-Cross R,Schirch V,Effects of amino acid sequence,buffers,and ionic strength on the rate and mechanism of deamidation of asparagine residues in small peptides.J Biol Chem,1991,266(33):22549-22556.
6Robinson NE,Robinson ZW,Robinson BR et al.Structure-dependent nonenzymatic deamidation of glutaminyl and asparaginyl pentapeptides.J Pept Res,2004,63(5):426-436.
7Teshima G,Porter J,Yim IL,et al.Deamidation of soluble CD4 at asparagine-52 results in reduced binding capacity for the HIV-1 envelope glycoprotein gp120.Biochemistry,1991,30(16):3916-3922.
8Aswad DW Paranandi MV,Schurter BT.Isoaspartate in peptides and proteins:formation,significance,and analysis.J Pharm Biomed Anal,2000,21(6):1129-1136.
9Schirch V,Delle Fratte S,di Salvo M.Detection of isoAspartate residues as a posttranslational modification of proteins and peptides.Methods Mol Biol,20012,194:269-276.
10Patel K,Borchardt RT.Chemical pathways of peptide degradation.Ⅱ.Kinetics of deamidation of an asparaginyl residue in a model hexapeptide.Pharm Res,1990,7(7):703-711.