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非水介质中脂肪酶催化的手性拆分研究进展 被引量：4

Advancements in chiral resolution catalyzed by lipase in non-aqueous media
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摘要 脂肪酶催化的外消旋体动力学拆分是不对称催化领域中极具吸引力且发展非常迅速的重要技术。对这一领域的最新研究进展进行了调研,并将注意力集中于脂肪酶在非水溶剂中的应用。引用最近五年中的一些文献案例,说明了脂肪酶作为立体选择性生物催化剂在外消旋体拆分中的多样化功能和应用。 Lipase-catalyzed kinetic resolution of racemates is considered to be one of the most fascinating topics in asymmetric catalysis. This review focuses on some of recent methodological advancements in this rapidly growing field demonstrating the versatility of the method in the resolution of race mates. The literature search was dated back to the last five years and covers some comprehensive examples concerning the use of lipases for the production of chiral intermediates. The main emphasis is put on the use of lipases in organic solvent systems.
作者 徐天闻 贾涛 许建和
机构地区 华东理工大学生物反应器工程国家重点实验室生物催化研究室
出处 《生物加工过程》 CAS CSCD 2005年第4期1-8,共8页 Chinese Journal of Bioprocess Engineering
基金 国家重大基础研究计划(973)项目资助(No.2003CB716008)
关键词 脂肪酶 非水介质 转酯反应 手性化合物 动力学拆分 lipase non-aqueous media transesterification chiral intermediate kinetic resolution
分类号 Q814.9 [生物学—生物工程]
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参考文献44

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共引文献22

同被引文献78

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引证文献4

二级引证文献15

生物加工过程
2005年 第4期

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