人原发性肝癌及癌周肝组织内C－myc表达研究

STUDY ON THE C-myc EXPRESSION IN HUMAN PRIMARY HEPATOCELLULAR CARCINOMA AND ITS PERIPHERAL TISSUE

应用免疫组化方法检测了５８例原发性肝癌组织石蜡切片中Ｃ－ｍｙｃ蛋白的表达。结果显示，Ｃ－ｍｙｃ蛋白在肝癌组织及其癌周肝组织中表达的阳性率分别为６８．９７％（４０／５８）及６５．５２％（３８／５８）。Ｃ－ｍｙｃ蛋白表达的增加与ＨＢｓＡｇ阳性、肝硬化及具有明显肝细胞不典型增生、癌周肝内转移、肿瘤无纤维包膜密切相关。值得注意的是，肝癌手术切除患者中，Ｃ－ｍｙｃ蛋白表达增加则肿瘤复发机率亦增高。文中还讨论了Ｃ－ｍｙｃ蛋白的表达与原发性肝癌发生的可能作用。

Immunohistochemical deteation of C-myc protein expression in 58 cases of primary hepato-cellular carcinoma(HCC)has been conducted in paraffin sections.It suggested that the positive rates of C-myc protein expression in HCC and its peripheral tissue were 68.97 %(40/58)and 65.52%(38/58),respec-tively.The increase of C-myc protein expression was closely related with HBsAg positive cirrhosis,atypicalproliferation of hepatocytes,metastasis in tumor surrounding tissue,and liver neoplasm without fibrous en-capsulation,C-myc protein expression increased significantly in HCC patients after hepatectomy,and thetumor recurrence rate was high.The possible action of C-myc protein expression in carcinogenesis of pri-mary HCC were.