摘要
背景与目的:有研究表明STI-571能抑制Bcr-Abl、C-kit、血小板衍生生长因子受体β(Platelet-derivedgrouthfactorreceptor-beta,PDGFR!)的酪氨酸激酶,从而抑制细胞的分化增殖和促进细胞凋亡,本研究旨在检测与STI-571相关的酪氨酸激酶受体在食管癌中的表达情况。方法:应用免疫组化的方法,检测50例食管癌组织、癌旁组织和正常组织中与STI-571相关的酪氨酸激酶受体C-kit和PDGFRβ的表达。结果:C-kit在癌组织、癌旁组织、正常组织中的强表达率较低,分别为4%、4%、12%,表达的差异无统计学意义。PDGFRβ在癌组织、癌旁组织、正常组织中的强表达率分别为68%、28%、28%,表达的差异有统计学意义。应用Logistic回归的方法,发现C-kit或PDGFRβ在癌组织、癌旁组织、正常组织中的强表达率与患者的性别、年龄、肿物的分化程度、肿物的浸润深度、肿物的部位、淋巴结转移情况和分期无相关。结论:食管癌组织中PDGFRβ的强表达率较高,且明显高于癌旁组织和正常组织。食管正常组织中C-kit的强表达率较低,癌组织和癌旁组织中C-kit的强表达率更低。
BACKGROUND & OBJECTIVE: Some researches have showed that STI-571 could inhibit tyrosine kinase of Bcr-Abl, C-kit, and platelet-derived growth factor receptor-beta (PDGFRβ), therefore, inhibit cell differentiation and proliferation and accelerate cell apoptosis. This study was to examine the expression of tyrosine kinase receptor C-kit and PDGFRβ, which is correlated to STI-571, in esophageal carcinoma. METHODS: The expression of C-kit and PDGFRβ in tumor tissue, para-tumor tissue, and normal tissue of 50 specimens of esophageal carcinoma was examined by immunohistochemistry. RESULTS: The strong expression rate of C-kit was low in tumor, para-tumor, and normal tissues (4%, 4%, and 12%, respectively), with no significant difference (P=0.220). The strong expression rate of PDGFRβ was significantly higher in tumor tissues than in para-tumor and normal tissues (68% vs. 28% and 28%, P=0.001). Logistic regression analysis revealed that the strong expression rate of C-kit and PDGFRI5 had no correlation to sex, age, differentiation degree, infiltrative depth, position, lymph node metastasis, and stage of esophageal carcinoma. CONCLUSIONS: The strong expression rate of PDGFRβ is significantly higher in tumor tissues than in para-tumor and normal tissues. The strong expression rate of C-kit in normal esophageal tissues is low, and it is lower in para-tumor and tumor tissues.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2006年第1期92-95,共4页
Chinese Journal of Cancer
基金
广州市科委基金(No.2002J1-C0151)~~