C-kit和PDGFRβ在食管癌组织中的表达及其临床意义

Expression and Significance of C-kit and Platelet-derived Growth Factor Receptor-beta (PDGFRβ) in Esophageal Carcinoma

背景与目的:有研究表明STI-571能抑制Bcr-Abl、C-kit、血小板衍生生长因子受体β(Platelet-derivedgrouthfactorreceptor-beta,PDGFR!)的酪氨酸激酶,从而抑制细胞的分化增殖和促进细胞凋亡,本研究旨在检测与STI-571相关的酪氨酸激酶受体在食管癌中的表达情况。方法:应用免疫组化的方法,检测50例食管癌组织、癌旁组织和正常组织中与STI-571相关的酪氨酸激酶受体C-kit和PDGFRβ的表达。结果:C-kit在癌组织、癌旁组织、正常组织中的强表达率较低,分别为4%、4%、12%,表达的差异无统计学意义。PDGFRβ在癌组织、癌旁组织、正常组织中的强表达率分别为68%、28%、28%,表达的差异有统计学意义。应用Logistic回归的方法,发现C-kit或PDGFRβ在癌组织、癌旁组织、正常组织中的强表达率与患者的性别、年龄、肿物的分化程度、肿物的浸润深度、肿物的部位、淋巴结转移情况和分期无相关。结论:食管癌组织中PDGFRβ的强表达率较高,且明显高于癌旁组织和正常组织。食管正常组织中C-kit的强表达率较低,癌组织和癌旁组织中C-kit的强表达率更低。

BACKGROUND ＆ OBJECTIVE： Some researches have showed that STI-571 could inhibit tyrosine kinase of Bcr-Abl, C-kit, and platelet-derived growth factor receptor-beta （PDGFRβ）, therefore, inhibit cell differentiation and proliferation and accelerate cell apoptosis. This study was to examine the expression of tyrosine kinase receptor C-kit and PDGFRβ, which is correlated to STI-571, in esophageal carcinoma. METHODS： The expression of C-kit and PDGFRβ in tumor tissue, para-tumor tissue, and normal tissue of 50 specimens of esophageal carcinoma was examined by immunohistochemistry. RESULTS： The strong expression rate of C-kit was low in tumor, para-tumor, and normal tissues （4%, 4%, and 12%, respectively）, with no significant difference （P=0.220）. The strong expression rate of PDGFRβ was significantly higher in tumor tissues than in para-tumor and normal tissues （68% vs. 28% and 28%, P=0.001）. Logistic regression analysis revealed that the strong expression rate of C-kit and PDGFRI5 had no correlation to sex, age, differentiation degree, infiltrative depth, position, lymph node metastasis, and stage of esophageal carcinoma. CONCLUSIONS： The strong expression rate of PDGFRβ is significantly higher in tumor tissues than in para-tumor and normal tissues. The strong expression rate of C-kit in normal esophageal tissues is low, and it is lower in para-tumor and tumor tissues.