3种药物联合治疗晚期胃癌的近期疗效和不良反应

AN ANALYSIS OF OXALIPLATIN COMBINED WITH FLUOROURACIL AND LEUCOVORIN IN 28 CASES WITH ADVANCED GASTRIC CANCER.

目的：观察奥沙利铂（L-OHP）联合氟尿嘧啶（5-Fu）和亚叶酸钙（CF）静脉滴注治疗晚期胃癌的近期疗效和不良反应。方法：48例晚期胃癌患者，第1天采用L-OPH 130mg／m^2，静脉滴注2h，CF200mg／m^2静脉滴注2h后（dl-5），5-Fu 500mg／m^2静脉滴注，（d1-5）。3周为1周期，每人病人接受2～4个周期。结果：全组完全缓解5例，部分缓解18例，近期有效率47．9％，不良反应主要为轻度Ⅰ°-Ⅱ°消化道反应及周围神经毒性。结论：奥沙利铂联系5-氟尿嘧啶和亚叶酸钙治疗晚期胃癌的近期疗效较好，不良反应轻微，适合年老体弱病人，值得进一步研究。

Objective： To evaluate the short- term efficacy and Side-effect Of Oxaliplatin combined with fluorouracil （t - Fu） and leucovrin （CF） in advanced gastric cancer. Methods： 48 cases with advanced gastric Cancer were freceived with Oxaliplatin 130 mg/m^2. d （2 hours intravenous infusion in the first day）, CF 200mg/ （m^2. d） 2 hours intravenous infusion then followed by 5 - Fu 500 nag/ （m^2. d） （intravenous infusion） dl - 5; A cycle was repeated every three weeks and 2 - 4 cycles were delivered for eachpafient. Results： The overall response rate was 47. 9% （CR, 5cases; PR, 18cases）; Conclusion： The L-OHP/5-Fu/CF regimen shows,s good efficacy with mild toxicity in treatment for advanced gastric cancer and its further investigation is worthwhile to study.