期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

磷酸奥司米韦合成路线图解 被引量：2

Graphical Synthetic Routes of Oseltamivir Phosphate
下载PDF
导出
作者 于慧杰 周伟澄
机构地区 上海医药工业研究院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2006年第1期66-69,共4页 Chinese Journal of Pharmaceuticals
基金 上海市科学技术委员会资助项目(04JC14068 04DZ05902)
关键词 磷酸奥司米韦 药物合成 神经氨酸酶抑制剂 口服制剂
分类号 TQ463 [化学工程—制药化工]
  • 相关文献

参考文献16

  • 1[1]Ward P,Small Ian,Smith,S,et al.Oseltamivir (Tamiflu) and its potential for use in the event of an influenza pandemic [J].J Antimicrob Chemother,2005,55 (Suppl.1):i5-i21.
  • 2[2]Brooks MJ,Sasadeusz JJ,Tannock GA.Antiviral chemothera peutic agents against respiratory viruses:where are we now and what's in the pipeline? [J].Curr Opin Pulm Med,2004,10 (3):197-203.
  • 3[3]Mendel DB,Roberts NA.In-vitro and in-vivo efficacy of influenza neuraminidase inhibitors [J].Curr Opin in Infect Disease,1998,11 (6):727-732.
  • 4[4]Federspiel M,Fisher R,Hennig M,et al.Industrial synthesis of the key precursor in the synthesis of the anti-influenza drug oseltamivir phosphate (Ro 64-0796/002,GS-4104-02)ethyl (3R,4S,5S)-4,5-epoxy-3-(1-ethyl-propoxy)-cyclohex-1-ene-1-carboxylate [J].Org Process Res Dev,1999,3(4):266-274.
  • 5[5]Bischofberger NW,Kim CU,Lew W,et al.Preparation of aminocyclohexenylcarboxylates and related compounds as neuraminidase inhibitors [P].US:5763483,1998-06-09.(CA1998,129:54135)
  • 6[6]Rohloff JC,Kent KM,Postich MJ,et al.Practical synthesis of the anti-influenza drug GS-4104 [J].J Org Chem,1998,63 (13):4545-4550.
  • 7龚晓明,许激扬,丁玉林.抗流感病毒新药oseltamivir的合成改进[J].中国新药杂志,2003,12(6):454-456. 被引量：4
  • 8[8]Terashima S,Ujita K,Kuwayama T,et al.Process for theproduction of 5-oxy-7-oxabicyclo-[4.1.0] hept-3-ene-3-carboxylic acid esters[P].WO:2001047906,2001-07-05.(CA 2001,135:76775)
  • 9[9]Stefan A,Martin K,Rene T,et al.Process for the preparation of Tamiflu and related 4,5-diaminoshikimic acid derivatives via Diels-Alder cycloaddition [P].EP:1127872,2001-08-29.(CA 2001,135:195452)
  • 10[10]Sugioka T,Ujita K,Kuwayama T,et al.Method for producing optically active 3-benzhydrylamine-4,5-dihydroxy-1cyclohecene-l-carboxylic acid ester[P].JP:2002088035,2002-03-27.(CA 2002,136:279213)

二级参考文献7

  • 1Laver G,Garman E. The origin and control of pandemic influenza[J]. Science ,2001,293(5536) :1776 - 1777.
  • 2Mcclellan K, Perry CM. Oseltamivir:a review of its use in influenza[J]. Drugs ,2001,61(2) :261 - 283.
  • 3Kim CU, Lew W, Williams MA, et al. Influenza neuraminidase inhibitors possessing a novel hydropHobic interaction in the enzymeactive site: design, synthesis, and structural analysis of carbocyclicsialic acid analogues with potent anti-influenza activity[J ]. J Am Chern Soc, 1997,119(4) :681 - 690.
  • 4Rchloff JC, Kent KM, Postiela M J, et al. Practical Total Synthesis of the Anti-Influenza Drug GS- 4104[J]. J Org Chem, 1998,63(13) :4545 - 4550.
  • 5Federspiel M, Fischer R, Hennig M, et al. Industral synthesis of the key precursor in the synthesis of the anti-influenza drug oseltamivir phosphate[J ]. Org Process Res Dev, 1999,3 (4) :266 -274.
  • 6Gololobov YG, Kasukhin LF. Recent advances in the staudinger reaction[J]. Tetrahedron, 1992,48(8) : 1353 - 1406.
  • 7Knapp S,Shieh WC,Jaramillo C, et al. Synthesis of the Ezomycin Octosyl Nucleoside[J ]. J Org Chem, 1994,59(5) : 946 - 948.

共引文献3

同被引文献13

  • 1MENNO D J,TRAN T T,TRUONGH K,et al.The writing committee of the world health organization(WHO) consultation on human influenza A/H5.avian influenza A(H5N1) infection in humans[J].New Engl.J.Med.,2005,353(13):1 374-1 385.
  • 2RCHLOFF J C,KENT K M,POSTICH M J,et al.Practical total synthesis of the anti-influenza drug GS-4104[J].J.Org.Chem.,1998,63(13):4 545-4 550.
  • 3FEDERSPIEL M,FISCHER R,HENNIG M,et al.Industrial synthesis of the key precursor in the synthesis of the antiinfluenza drug oseltamivir phosphate(Ro 64-0796/002,GS-4104-02):ethyl(3R,4S,5S)-4,5-epoxy-3-(1-ethylpropoxy)-cyclohex-1-ene-1-carboxylate[J].Org.Proc.Res.Dev.,1999,3(4):266-274.
  • 4BISCHOFBERGER N W,KIM C U,LEW W,et al.Preparation of aminocyclohexenyl-carboxylates and related compounds as neuraminidase inhibitors:US,5 763 483[P].1998-06-09.
  • 5STEFAN A,MARTIN K,RENE T,et al.Process for the preparation of tamiflu and related 4,5-diaminoshikimic acid derivatives via Diels-Alder cycloaddition:EP,1 127 872[P].2001-08-29.
  • 6Ward P,Small I,Smith J,et al.Oseltamivir (Tamiflu) and its potential for use in the event of an influenza pandemic[J].J Antimicrob Chemother,2005,55(Suppl.1):i5-i21.
  • 7The Writing Committee of the World Health Organization (WHO) Consultation on Human Influenza A/H5.Avian Influenza A (H5N1) Infection in Humans[J].New Engl J Med,2005,353(13):1374-1385.
  • 8Rchloff JC,Kent KM,Postich MJ,et al.Practical total synthesis of the anti-influenza drug GS-4104[J].J Org Chem,1998,63(13):4545-4550.
  • 9Federspiel M,Fischer R,Hennig M,et al.Industrial synthesis of the key precursor in the synthesis of the antiinfluenza drug oseltamivir phosphate(Ro 64-0796/002,GS-4104-02):ethyl(3R,4S,5S)-4,5-epoxy-3-(1-ethy1-propoxy)-cyclohex-1-ene-1-carboxylate[J].Org Proc Res Dev,1999,3(4):266-274.
  • 10梅尔 HJ.将叠氮化物转变成酰胺的膦还原法:中国,1298868(2001-06-13)[J].CA,2001,135:6109-6109.

引证文献2

二级引证文献4

中国医药工业杂志
2006年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部