捂热综合征患儿血清心肌肌钙蛋白Ⅰ的变化及意义

Change and significance of serum cardiac troponinⅠ in infant Muggy syndrome

目的:探讨血清心肌肌钙蛋白Ⅰ(cT n I)及肌酸磷酸激酶同工酶(CK-M B)测定对捂热综合征患儿心肌损害的早期诊断价值。方法:选择捂热综合征患儿(观察组)及对照组各30例于入院后1,7 d测定血清cT n I及CK-M B水平。结果:观察组入院后1d血清cT n I及CK-M B明显高于对照组(P<0.01),治疗后呈逐渐下降趋势。血清cT n I及CK-M B对心肌损害诊断的敏感性无显著性差异(P>0.05)。结论:血清cT n I及CK-M B可用于捂热综合征心肌损害的早期诊断,进而对于捂热史不清的捂热综合征诊断具有重要意义。

Objective To evaluate the value of cardiac troponin Ⅰ （cTnI） and creatine kinase MB （CK-MB） to earlier diagnosis on myocardial injury in infant Muggy syndrome. Methods Dynamic variation of serum cTnI and CK-MB levels were measured on the first and seventh day after admission in 30 infant Muggy syndrome infants and 30 control infants. Results Serum cTnI and CK-MB levels of infant Muggy syndrome infants were significantly higher than those in control group （P〈0.01） on the first day after admission. The levels of serum cTnI and CK-MB were gradually decreased after treatment in infant Muggy syndrome infants. There was no significant difference of sensitivity between cTnI and CK-MB in serum for diagnosing myocardial injury （P〉0.05）. Conclusion The determination of cTnI and CK-MB levels can help the prediction of myocardial injury in infant Muggy syndrome and be of important significance to diagnosis of infant Muggy syndrome with unclear history of muggy.